Evidence map›Paper›PMID 41074145›Full record

ArticleCancer cell international2025

Centromere protein I facilitates breast cancer tumorigenesis and disease progression through modulation of Wnt/β-Catenin signaling.

Chaoshen Wu, Yibing Zhou, Yuxiao Mu, Yijie Cheng, Wenqian Xu, Mengna Huang, Jingyuan Xu, Ming Li, Jianfeng Gu, Xuli Meng and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chaoshen Wu *Central Laboratory, Department of Scientific Research, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, 215500, Changshu, Suzhou, Jiangsu Province, China.
Yibing Zhou *Central Laboratory, Department of Scientific Research, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, 215500, Changshu, Suzhou, Jiangsu Province, China.
Yuxiao Mu *General Surgery, Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang Province, China.
Yijie ChengDepartment of Pharmacy, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, 215500, Changshu, Suzhou, Jiangsu Province, China.
Wenqian XuDepartment of Thyroid and Breast Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, 215500, Changshu, Suzhou, Jiangsu Province, China.
Mengna HuangCentral Laboratory, Department of Scientific Research, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, 215500, Changshu, Suzhou, Jiangsu Province, China.
Jingyuan XuSchool of Biology and Food Engineering, Suzhou University of Technology, 215500, Changshu, Suzhou, Jiangsu Province, China.
Ming LiDepartment of General Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, 215500, Changshu, Suzhou, Jiangsu Province, China.
Jianfeng GuDepartment of General Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, 215500, Changshu, Suzhou, Jiangsu Province, China. jscsgjf@sina.cn.
Xuli MengGeneral Surgery, Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang Province, China. mxlmail@126.com.
Da QianCentral Laboratory, Department of Scientific Research, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, 215500, Changshu, Suzhou, Jiangsu Province, China. qianda0215@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer (BCa) is a major contributor to female mortality worldwide. Treatment resistance and tumor heterogeneity contribute to the lack of effective therapeutic targets, posing a significant challenge in BCa management. CENPI, a core centromere protein involved in chromosome segregation, has emerging evidence implicating it in oncogenesis across diverse malignancies. However, its functional and molecular mechanisms in BCa remain unclear.

methodsWe analyzed CENPI expression and its clinical significance by using the BCa dataset from the Cancer Genome Atlas (TCGA) and immunohistochemical staining of 3 human BCa tissue samples. Cellular functional assays and mice xenograft models were utilized to assess the effects of CENPI on BCa growth. RNA sequencing combined with bioinformatics analysis was conducted to elucidate the molecular mechanisms underlying CENPI function, with further validation through Western blotting, immunofluorescence, and TOP/FOP flash assays.

resultsCENPI was aberrantly overexpressed in BCa, with elevated expression levels strongly associated with disease progression and poor prognosis. Functional assays demonstrated that CENPI significantly promoted breast carcinogenesis in both cellular and animal models. Mechanistically, CENPI increased BCa progression and malignant phenotypes by modulating the Wnt/β-catenin axis.

conclusionsCENPI is a critical oncogene in BCa, driving tumorigenesis and disease progression via the Wnt/β-catenin axis, which represents a promising biomarker and therapeutic target for BCa.

Indexed as

Breast cancerCENPIChromosomeMitosisWnt/β-catenin signaling

Identifiers

PMID41074145
PMCPMC12512846

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