ArticleCell communication and signaling : CCS2025
Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB
Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Orally bioavailable CBResearch square · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundCannabinoid type 2 receptor (CB
methodsTo this end, we used two CB
resultsIn both cases, their i.p. administration improved the neurological status of these mice, preserved their spinal motor neurons and attenuated glial reactivity. They also recovered those muscle fibers denervated by the pathology in SOD-1 transgenic mice. To confirm that the efficacy of RO-6871304 is not derived from a possible BBB damage in amyotrophic lateral sclerosis mice that may allow this agonist to reach the CNS, we analyzed their concentrations in neural tissues after acute administration in both experimental models. Our data confirmed that RO-6866945 was detected in the brain, while RO-6871304 was not, whereas both compounds were found in the plasma.
conclusionsIn summary, our data suggest that CB
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.