ArticleHealth and quality of life outcomes2025
Quality of life in people with herpes zoster: a cross-sectional study in China.
Article in Health and quality of life outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Efficacy of Ultrasound-Guided Intercostal Nerve Block With Liposomal Bupivacaine for Treating Postherpetic Neuralgia in Adult Patients.The Kaohsiung journal of medical sciences · 2026Article
- Disease burden and health-related quality of life among adults aged 50 years or older with herpes zoster in Huzhou, China.Frontiers in public health · 2026Article
- Development and validation of a machine learning model for predicting postherpetic neuralgia risk.Frontiers in neurologyArticle
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10 authors.
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Abstract
introductionHerpes zoster (HZ), affecting 14.9 million people aged ≥ 50 globally in 2020, imposes a growing burden in aging populations due to its association with chronic pain, psychological distress, and socioeconomic disparities. This study aimed to evaluate health-related quality of life (HRQoL) among people with HZ and explore its socioeconomic and clinical determinants in China.
methodsWe conducted a cross-sectional survey to investigate the HRQoL of 2,566 herpes zoster patients across seven Chinese cities using the EQ-5D-5 L and VAS-100 instruments. Multivariate linear regression models quantified the association of age, income, insurance type, herpes zoster related pain, complications, and comorbidities with HRQoL.
resultsThe average EQ-5D score was 0.83, and the average VAS score was 71.49 among herpes zoster patients in China. Patients aged ≥ 70 years exhibited the most severe decline in both EQ-5D (β = -0.110, p < 0.01) and VAS-100 scores (β = -8.811, p < 0.01), with mobility limitations (OR = 3.696, p < 0.01) and self-care deficits (OR = 2.295, p < 0.01) disproportionately affecting this group. Herpes zoster related pain was associated with lower HRQoL (EQ-5D:β = -0.126, p < 0.01). Patients with comorbidities faced significant HRQoL reductions (VAS: β = -4.014, p < 0.01).
conclusionOur study found that Chinese herpes zoster patients exhibited higher HRQoL scores compared to those reported in most of other studies. Advanced age, lower education levels, inadequate insurance coverage, and pain occurrence were all significantly associated with diminished HRQoL. The observed disparities in HRQoL reductions among patient subgroups highlight the need to address health equity through curative interventions and preventive strategies.
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