Evidence map›Paper›PMID 41074034›Full record

ReviewJournal of nanobiotechnology2025

Scientometric analysis of extracellular vesicles in vision science (up to 2024).

Fei Liao, Francisco Germain, Li Ma, Chao Wei, Ting Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fei LiaoEye Hospital of Shandong First Medical University (Shandong Eye Hospital), Eye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University, Jinan, 250021, China.
Francisco GermainDepartment of Systems Biology, Laboratory of Visual Neurophysiology, University of Alcalá, 28871, Alcalá de HenaresMadrid, Spain.
Li MaState Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, School of Ophthalmology, Qingdao Eye Hospital of Shandong First Medical University, Qingdao , 266071, China.
Chao Wei *State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, School of Ophthalmology, Qingdao Eye Hospital of Shandong First Medical University, Qingdao , 266071, China.
Ting Wang *Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Eye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University, Jinan, 250021, China. wting@sdfmu.edu.cn.

Funding

co-funded by the European Union and the University of Alcalá PIUAH22/CCS.21Educational and Teaching Reform Research Project of Shandong First Medical University XM2024001National Natural Science Foundation of China 82271052Projects of Medical and Health Technology Development Program in Shandong Province 202207020361Qingdao Medical and Health Research Guidance Program for 2022 2022-WJZD202Shandong Provincial Key Research and Development Program 2024CXGC010617Taishan Scholar Program of Shandong Province tstp20240858
6 · The paper itself

Abstract

backgroundExtracellular vesicles (EVs) in vision science have gained significant attention. However, a comprehensive scientometric analysis of the key major contributors, the current research landscape, and development trends is still lacking.

objectivesTo detect and visualize the research strengths, knowledge base, and research frontiers of EVs in vision science.

methodsPublications of EVs on vision science were systematically collected from Web of Science, PubMed, Scopus, and Embase, covering the inception of each database up to December 31, 2024. Following data cleaning, a bibliometric assessment was conducted primarily based on VOSviewer and CiteSpace platforms. Key analysis included temporal publication trends, co-authorship patterns, the knowledge base, and the thematic evolution of research trends.

resultsA total of 427 original research articles were analyzed, with an average of 25.69 citations per article and an H-index of 55. The global annual cumulative publication showed exponential growth across three phases: a silent period (2003-2012, 8 articles), gradual growth (2013-2019, 67 articles), and a sharp surge from 2020 onward (352 articles). United States and China led in publication output, with the University of California System emerging as the most collaborative institution. The knowledge base comprises thirteen well-established themes, which originated around 2009. Fifteen salient research frontier themes have emerged, most of which remain in the developmental phase.

conclusionThe roles of EVs in pathophysiology, diagnostic, and therapeutic potential in vision science have been extensively explored; however, notable limitations and gaps remain, warranting further investigation. Moreover, the clinical translation of EVs-based applications faces significant challenges.

Indexed as

BibliometricsExtracellular VesiclesVision, OcularHumansBiomarkerCorneaExtracellular vesiclesGlaucomaMSCsRetinaRPEVision scienceVisualization

Identifiers

PMID41074034
PMCPMC12514847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.