ArticleBMC pediatrics2025
Clinical characteristics of children with idiopathic nephrotic syndrome infected with SARS-CoV-2: a single-center retrospective cohort study.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdiopathic nephrotic syndrome (INS) is the most common kidney disease in children; however, the characteristics of kidney involvement, which occurs following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children with INS, remain unclear. Therefore, in the present study, we investigated the clinical characteristics of children with INS infected with SARS-CoV-2.
methodsWe retrospectively enrolled 20 children with INS infected with SARS-CoV-2, and 50 without underlying diseases infected during the same period as controls. Data on sex, age, mode of transmission, vaccination status, duration of illness, clinical symptoms, myocardial enzyme levels, D-dimer levels, kidney function, incidence of acute kidney injury (AKI), respiratory support, immunoglobulin levels, and absolute lymphocyte values were collected and compared between the groups. Information regarding the type of pathology, immunosuppressant use, and time of relapse in the INS group was also collected.
resultsIn the INS group, 10 patients had a history of intrafamilial transmission. All cases had mild symptoms, mostly cough and fever, with an average disease duration of 1 week. The two groups showed no significant differences in sex, age, mode of transmission, vaccination, duration of illness, clinical symptoms, elevated D-dimer level, AKI, or respiratory support. A significant difference was observed only in myocardial enzyme elevations (P<0.001
conclusionsSARS-CoV-2 infections in children with INS were mainly intrafamilial, and mostly mild. SARS-CoV-2 infection was associated with relapse in INS, and may lead to complications such as myocardial enzyme elevations, AKI, deterioration of kidney function, while upregulated steroid therapy might be effective in relapse cases of children with SSNS. Further, we found that healthy children are at risk of new-onset INS following SARS-CoV-2 infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.