Evidence map›Paper›PMID 41073932›Full record

ArticleBMC infectious diseases2025

Impact of vaccination on SARS-CoV-2 infections and long COVID symptoms: a cross-sectional study in China.

Xiaolong Yan, Xin Zhao, Hao Wang, Yin Du, Li Liu, Jianhua Liu, Qi Wang, Sheng Wei

Abstract read
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaolong Yan *Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China.
Xin Zhao *Center for Disease Control and Prevention, Yichang, Hubei, China.
Hao WangDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China.
Yin DuCenter for Disease Control and Prevention, Yichang, Hubei, China.
Li LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China.
Jianhua LiuCenter for Disease Control and Prevention, Yichang, Hubei, China.
Qi WangDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China. wangqi_tj@hust.edu.cn.
Sheng WeiDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China. ws2008cn@gmail.com.

Funding

National Key Research and Development Program of China 2022YFC2305103National Natural Science Foundation of China 72061137006
6 · The paper itself

Abstract

backgroundFollowing the adjustment of the dynamic zero-COVID-19 strategy, China has witnessed a rapid increase in COVID-19 cases. However, the relationship between diverse vaccination statuses and the spectrum of symptom presentation, disease severity, and long-term post-COVID conditions remains to be fully understood. This study aimed to assess the impact of vaccination on the incidence of SARS-CoV-2 infections, the manifestation of acute symptoms, and the occurrence of long-term symptoms post-infection within the context of China's revised pandemic prevention and control measures.

methodsThis study investigated 6,572 participants from the Yichang COVID-19 Antibody Longitudinal Survey (YC-CALS) in March 2023, focusing on demographic and health-related information, including vaccination history, infection status, and symptomatology. Univariate and multivariate analysis methods were used to determine the correlations between vaccination status and COVID-19 outcomes.

resultsAmong the surveyed participants, 85.91% reported positive for SARS-CoV-2. Of those who were positive, 96.79% experienced at least one common symptom, with fever (79.34%), cough (62.56%), and fatigue (60.59%) being the most reported symptoms. Despite the high incidence of symptoms, only 2.05% of those who tested positive needed hospitalization. Importantly, symptoms such as palpitations, chest pain, and shortness of breath persisted beyond 90 days in certain individuals. Booster shots significantly reduced the risk of specific symptoms including dyspnea, eye soreness and fatigue, and gastrointestinal discomfort (P < 0.05). Vaccination beyond 12 months significantly increased symptoms such as decreased sense of smell, palpitations, and chest distress (P < 0.05). Additionally, the study found a positive correlation between the timing of vaccination and the development of long COVID symptoms, with individuals vaccinated more than 12 months prior exhibiting a higher likelihood of enduring symptoms such as fatigue (OR = 1.218, P = 0.023) and headache dizziness (OR = 1.244, P = 0.038) for over one month.

conclusionsThe findings highlight the critical importance of vaccination in controlling the spread of COVID-19 and reducing symptoms and disease prognosis, providing important insights for future vaccine policy.

Indexed as

COVID-19COVID-19 VaccinesSARS-CoV-2VaccinationAdolescentAdultAgedChinaCross-Sectional StudiesFatigueFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedCOVID-19 VaccinesCOVID-19Long COVIDSymptomsVaccination

Identifiers

PMID41073932
PMCPMC12512682

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.