Evidence map›Paper›PMID 41073862›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Digital PCR Analysis of Methylated Circulating Tumor DNA.

Rikke Fredslund Andersen, Tina Brandt Christensen, Torben Frøstrup Hansen

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rikke Fredslund AndersenDepartment of Biochemistry and Immunology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark. rikke.fredslund.andersen@rsyd.dk.
Tina Brandt ChristensenDepartment of Biochemistry and Immunology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
Torben Frøstrup HansenDepartment of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods for analyzing circulating tumor DNA (ctDNA) in a fast, quantitative, and reproducible way may help clinical implementation. Analyses of ctDNA can be performed without prior analysis of tumor tissue from patients by using tumor-specific methylations as targets. Digital PCR measurements are quantitative and enable the possibility to monitor dynamics of ctDNA during treatment, which has been shown to correlate with patient outcome. The protocol describes methylation analysis of plasma samples where results are available in a timely manner providing the opportunity to adjust treatment of cancer patients.

Indexed as

Biomarkers, TumorCirculating Tumor DNADNA MethylationNeoplasmsPolymerase Chain ReactionHumansBiomarkers, TumorCirculating Tumor DNACancerCirculating tumor DNADroplet digital PCRLiquid biopsyMethylationPlasma

Identifiers

PMID41073862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.