ArticleClinical rheumatology2025
A retrospective study on pancreatic and extra-pancreatic characteristics of IgG4-related disease.
Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Clinical characteristics of IgG4-related disease patients with different serum IgG4 levels: A single-center retrospective study.The Journal of international medical research · 2026Observational
- Asymptomatic Isolated IgG4-related Colopathy.Digestive diseases and sciences · 2026Article
- Elevated CA19-9 in IgG4-Related Autoimmune Pancreatitis: A Single-Center Retrospective Cohort Study.International journal of general medicine · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundIgG4-related autoimmune pancreatitis (IgG4-AIP) is a rare inflammatory condition of the pancreas that is mediated by autoimmune mechanisms and constitutes the most prevalent manifestation of IgG4-related disease (IgG4-RD). This study aims to analyze and compare the clinical characteristics between patients with pancreatic involvement and those without in the context of IgG4-RD. Furthermore, it seeks to explore the differences in clinical features among IgG4-AIP patients with and without bile duct involvement.
methodsA retrospective analysis of clinical data was conducted in this study involving 82 patients with IgG4-RD who were admitted to Yichang Central People's Hospital between January 2019 and December 2024
resultsAmong the 82 patients with IgG4-RD, 40 (48.78%) patients exhibited pancreatic involvement, while 42 (51.22%) patients had non-pancreatic involvement. The incidence of male patients was higher in the pancreatic involvement group compared to the non-pancreatic involvement group (87.50% vs. 66.67%, P < 0.05). Serum IgG4 levels in patients with IgG4-AIP were significantly elevated compared to those in patients without pancreatic involvement (P < 0.05). IgG4-AIP patients were more likely to exhibit involvement of two or more organs simultaneously, with a greater tendency for bile duct involvement (P < 0.05). In contrast, the incidence of pulmonary or salivary gland involvement was relatively low (P < 0.05). In addition, IgG4-AIP patients with bile duct involvement exhibited significantly higher levels of basophils, eosinophils, alkaline phosphatase (ALP), bilirubin, and erythrocyte sedimentation rate (ESR) compared to those without bile duct involvement (P < 0.05).
conclusionsIgG4-AIP presents with more complex clinical characteristics. Clinicians should develop a thorough understanding of these features and formulate individualized diagnostic and therapeutic strategies to improve patient outcomes.
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