Evidence map›Paper›PMID 41073809›Full record

ArticleAnnals of hematology2025

Haemoglobin variants in nigeria: real-world data from a point-of-care device.

Taiwo Kotila, Oladapo Aworanti, Chima Akunwata, Peter Ogundeji, Samuel Oresanya, Adetunji Adewale, Raphael Alabi, Foluke Fasola, John Olaniyi

Abstract read
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In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances and Gaps in Global Newborn Screening for Sickle Cell Disease.International journal of neonatal screening · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Taiwo KotilaDepartment of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria. tkotila@com.ui.edu.ng.ORCID http://orcid.org/0000-0001-7355-7166
Oladapo AworantiDepartment of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Chima AkunwataDepartment of Haematology, University College Hospital, Ibadan, Nigeria.
Peter OgundejiDepartment of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Samuel OresanyaDepartment of Haematology, University College Hospital, Ibadan, Nigeria.
Adetunji AdewaleDepartment of Haematology, University College Hospital, Ibadan, Nigeria.
Raphael AlabiDepartment of Haematology, University College Hospital, Ibadan, Nigeria.
Foluke FasolaDepartment of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
John OlaniyiDepartment of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-middle-income countries (LMICs) have used cellulose acetate electrophoresis preferentially in the diagnosis of haemoglobinopathies. Recently, point-of-care (POC) devices have made the diagnosis faster and cheaper. This study analyzed results of haemoglobin variants obtained from 'Gazelle', a POC device. A retrospective data from a tertiary hospital over a two-year period. Hereditary persistence of fetal haemoglobin (HPFH) and beta thalassaemia trait were diagnosed using a cut off of HbF of ≥ 15% and HbA2 of ≥ 3% respectively, other haemoglobin variants were as reported by the instrument. Results were compared between women accessing antenatal care and those for premarital counselling ('controls') with in-patients. A total of 1104 samples were sent for analysis during the period, but 1093 were analyzed because 11 samples were indeterminate. The distribution of the genotypes of the control was different from that of the in-patients (P = 0.02), but was comparable to that of an infant population (P = 0.71). The prevalence of HPFH and BTT were 21% (229/1093) and 36% (391/1093) respectively. The prevalence of HPFH was highest among HbSS (47.8%) compared to HbAA (22%) or HbAS (10.4%); P < 0.001. The prevalence of BTT was highest among HbAA (55.1%) compared to HbAS (5.4%) and HbSS (1.1%); P < 0.001. The prevalence of HPFH did not differ between the in-patients and the controls 23.1% vs. 19.1% respectively (p = 0.33) but the prevalence of BTT was higher among the controls (36% vs. 38%; P = 0.001). The high prevalence of sickle cell anaemia, HPFH and BTT in the community may be interrelated.

Indexed as

HemoglobinopathiesHemoglobins, AbnormalPoint-of-Care SystemsAdultbeta-ThalassemiaFemaleHumansMaleNigeriaPregnancyRetrospective StudiesHemoglobins, AbnormalBeta thalassaemiaEpidemiologyHaemoglobin electrophoresisHereditary persistence of fetal haemoglobinPoint of care test

Identifiers

PMID41073809
PMCPMC12619758

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.