Evidence map›Paper›PMID 41073748›Full record

ArticlePediatric radiology2025

A standardized universal protocol for using adjunct abdominal ultrasound at the time of diagnosis for suspected necrotizing enterocolitis.

Clifford Hegedus, Clare Essex, Katherine Vincent, Alanna Shiflett, Leslie Spence, Jeanne Hill, Katherine E Chetta

Abstract read
In one paragraph

Article in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Clifford HegedusC.P. Darby Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Medical University of South Carolina, 10 McClennan Banks Drive, MSC 915 SJCH Room 2190, Charleston, SC, 29425, United States. hegedusc@chop.edu.
Clare EssexMedical University of South Carolina, Charleston, United States.
Katherine VincentC.P. Darby Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Medical University of South Carolina, 10 McClennan Banks Drive, MSC 915 SJCH Room 2190, Charleston, SC, 29425, United States.
Alanna ShiflettC.P. Darby Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Medical University of South Carolina, 10 McClennan Banks Drive, MSC 915 SJCH Room 2190, Charleston, SC, 29425, United States.
Leslie SpenceDepartment of Pediatric Radiology, Shawn Jenkins Children's Hospital, Medical University of South Carolina, Charleston, United States.
Jeanne HillDepartment of Pediatric Radiology, Shawn Jenkins Children's Hospital, Medical University of South Carolina, Charleston, United States.
Katherine E ChettaC.P. Darby Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Medical University of South Carolina, 10 McClennan Banks Drive, MSC 915 SJCH Room 2190, Charleston, SC, 29425, United States. chetta@musc.edu.

Funding

Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Caroline Westwater · 2020 to 2026
$8.8M
South Carolina Clinical & Translational Research Institute (SCTR)KL2TR001452 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCRAE-CLARK, AIMEE L · 2015 to 2024
$5.9M
NCATS NIH HHS KL2 TR001452NCATS NIH HHS KL2TR001452NIDDK NIH HHS P30 DK123704
6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) remains a highly morbid disease for preterm infants. The use of adjunct abdominal ultrasonography improves the evaluation of early or uncertain cases of NEC. No institutions have reported implementing a standardized adjunct abdominal ultrasound guideline and universally adopting adjunct abdominal ultrasound in routine neonatal practice for the evaluation of NEC.

objectiveTo determine if a standardized, adjunct abdominal ultrasound guideline for diagnosing NEC is feasible and beneficial for the routine detection of pathologic abdominal findings in NEC. MATERIALS AND

methodsThis retrospective study was conducted in an 82-bed level IV academic neonatal intensive care unit from February 2023-April 2024. Unit guidelines were updated in February 2023 to recommend the addition of an adjunct abdominal ultrasound to evaluate NEC universally at the time of initial evaluation. Imaging data was abstracted from a post-implementation observation period of 15 months. Implementation feasibility was assessed. Sonographic findings consistent with NEC were described after implementing standardized sonography protocols.

resultsAdjunct abdominal ultrasound was performed in 22 of 23 cases (96%) of NEC following guideline implementation. Twenty ultrasounds (90%) had at least one finding suggestive of NEC, and 12 (55%) had multiple findings suggestive of NEC. Seven ultrasounds (32%) showed findings of NEC in cases with unremarkable initial abdominal radiographs. Two NEC cases had radiographic findings without abdominal ultrasound findings. The sensitivity of abdominal ultrasound for NEC was 0.91. In 59% of cases, abdominal ultrasound findings resulted in a higher modified Bell's stage when compared to initial abdominal radiograph findings.

conclusionImplementing a standardized adjunct abdominal ultrasound guideline to assist with the initial diagnostic evaluation of NEC is feasible and may aid in diagnosis of NEC.

Indexed as

Enterocolitis, NecrotizingAbdomenFemaleHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMalePractice Guidelines as TopicRetrospective StudiesUltrasonographyEnterocolitis, necrotizingInfant, newbornInfant, prematureIntensive care units, neonatalRadiography, abdominalUltrasonography

Identifiers

PMID41073748
PMCPMC12708678

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.