Efficient synthesis of aqueous soluble Silymarin nanocrystals from Silybum marianum and assessment of their antibacterial and cytotoxicity insights.

Iman Sirvani, Zahra Sabouri, Asma Mostafapour, Majid Darroudi

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Facile and efficient synthesis of silver nanoparticles using Stachys viscosa with phenolic profiling, antioxidant potential and cytotoxic activity.Scientific reports · 2026
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5 · Who and what money

Authors and funding

4 authors.

Iman SirvaniDepartment of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Zahra SabouriDepartment of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Asma MostafapourDepartment of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Majid DarroudiNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. majiddarroudi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, aqueous-soluble silymarin nanocrystals (NCs) were prepared using Silybum marianum extract via the solvent evaporation method. The synthesized silymarin NCs were identified by XRD, FESEM/TEM, EDX, FT-IR, and UV-Vis procedures. The XRD pattern of silymarin NCs has shown amorphous structures. FESEM and TEM images of silymarin NCs exhibited spherical shapes with a size of about 23.14 nm. Also, the FTIR spectra revealed the presence of the functional groups in silymarin and silymarin NCs. The UV-Vis results of silymarin NCs donated strong absorption bands in the range of 230 and 285 nm. The results of the MTT assay indicated that silymarin NCs had minimum toxicity on cancer MDA-MB-231 cells with an IC

Indexed as

Anti-Bacterial AgentsNanoparticlesSilybum marianumSilymarinCell Line, TumorCell SurvivalEscherichia coliHumansMicrobial Sensitivity TestsPlant ExtractsSolubilitySpectroscopy, Fourier Transform InfraredStaphylococcus aureusWaterX-Ray DiffractionAnti-Bacterial AgentsPlant ExtractsSilymarinWaterAntibacterial activityAqueous soluble silymarin nanocrystalsSilybum MarianumSolvent evaporation

Identifiers

PMID41073635

DOI10.1038/s41598-025-19501-w

PMCPMC12514062

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