Evidence map›Paper›PMID 41073618›Full record

ArticlePsychopharmacology2026

Daily self-assessment within a regimen of microdosing indicates enhanced psychological functioning on microdosing days relative to non-microdosing days.

Michelle St Pierre, Elena Argento, Jordyn Cates, Pamela Kryskow, Kalin Harvey, Paul Stamets, Eesmyal Santos-Brault, Sarah A Paschall, Kim P C Kuypers, Joseph Rootman and 1 more

Abstract read
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In one paragraph

Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michelle St PierreDepartment of Psychology, University of British Columbia, Kelowna, BC, Canada. michelle.stpierre@ubc.ca.ORCID http://orcid.org/0000-0002-4522-3166
Elena ArgentoDepartment of Psychology, University of British Columbia, Kelowna, BC, Canada.
Jordyn CatesDepartment of Psychology, University of British Columbia, Kelowna, BC, Canada.
Pamela KryskowDepartment of Family Medicine, University of British Columbia, Vancouver, BC, Canada.
Kalin HarveyQuantified Citizen Technologies Inc., Vancouver, BC, Canada.
Paul StametsFungi Perfecti, LLC, Olympia, United States.
Eesmyal Santos-BraultQuantified Citizen Technologies Inc., Vancouver, BC, Canada.
Sarah A PaschallQuantified Citizen Technologies Inc., Vancouver, BC, Canada.
Kim P C KuypersDepartment of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Joseph RootmanDepartment of Psychology, University of British Columbia, Kelowna, BC, Canada.
Zach WalshDepartment of Psychology, University of British Columbia, Kelowna, BC, Canada.

Funding

Mitacs Mitacs
6 · The paper itself

Abstract

rationaleRepeated self-administration of small doses of psychedelics, known as microdosing, has been associated with perceived improvements in psychological functioning. However, few studies have examined effects at the daily level.

objectivesDrawing on data from a naturalistic, prospective, international survey of adults who microdose (N = 1435), we assessed self-reported within-person changes between microdosing days and non-microdosing days across six domains of psychological functioning.

resultsUsing multi-level modeling, we identified higher (p <.001) ratings of Wellbeing (F(1,768) = 160.15), Productivity (F(1,917) = 108.69), Creativity (F(1,899) = 25.99), Connectedness (F(1,859) = 253.4), Contemplation (F(1,864) = 180.5), and Focus (F(1,846) = 191.72) on microdosing days compared to non-microdosing days. For the domain of Creativity, increased scores were more pronounced among respondents with a history of using larger doses of psychedelics (F(1,899) = 4.40, p = .04).

conclusionsGiven the observational and exploratory nature of this study, these findings should be interpreted with caution; nonetheless, the prospective data provides valuable real-time insights while reducing recall bias.

Indexed as

HallucinogensSelf-AssessmentAdultDose-Response Relationship, DrugFemaleHumansMaleProspective StudiesPsychological Well-BeingSelf AdministrationSelf ReportYoung AdultHallucinogensCitizen scienceMental healthMicrodosingPsilocybinPsychedelics

Identifiers

PMID41073618

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.