Evidence map›Paper›PMID 41073606›Full record

ArticleScientific reports2025

Identification of genetic variants associated with lupus nephritis in a Taiwanese cohort through systematic genetic screening.

John Cheng-Han Lee, Kuo-Sheng Hung, Jia-Huei Lyu, Yi-Jen Hung, Hsiang-Cheng Chen, San-Yuan Kuo, Shi-Jye Chu, Chun-Chi Lu, Fu-Chiang Yeh, Feng-Cheng Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

John Cheng-Han LeeDivision of Rheumatology/Immunology/Allergies, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, No. 325, Sec, 2, Cheng-Gong Road, Neihu 114, Taipei, Taiwan, ROC.
Kuo-Sheng HungCenter for Precision Medicine and Genomic, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
Jia-Huei LyuCenter for Precision Medicine and Genomic, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
Yi-Jen HungDivision of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
Hsiang-Cheng ChenDivision of Rheumatology/Immunology/Allergies, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, No. 325, Sec, 2, Cheng-Gong Road, Neihu 114, Taipei, Taiwan, ROC.
San-Yuan KuoDivision of Rheumatology/Immunology/Allergies, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, No. 325, Sec, 2, Cheng-Gong Road, Neihu 114, Taipei, Taiwan, ROC.
Shi-Jye ChuDivision of Rheumatology/Immunology/Allergies, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, No. 325, Sec, 2, Cheng-Gong Road, Neihu 114, Taipei, Taiwan, ROC.
Chun-Chi LuDivision of Rheumatology/Immunology/Allergies, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, No. 325, Sec, 2, Cheng-Gong Road, Neihu 114, Taipei, Taiwan, ROC.
Fu-Chiang YehDivision of Rheumatology/Immunology/Allergies, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, No. 325, Sec, 2, Cheng-Gong Road, Neihu 114, Taipei, Taiwan, ROC.
Feng-Cheng LiuDivision of Rheumatology/Immunology/Allergies, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, No. 325, Sec, 2, Cheng-Gong Road, Neihu 114, Taipei, Taiwan, ROC. lfc10399@gmail.com.

Funding

Tri-Service General Hospital TSGH-B-112020、TSGH-B-113022
6 · The paper itself

Abstract

Lupus nephritis (LN) is a common manifestation of systemic lupus erythematosus (SLE), affecting about half of the patients. This research uses genotype-phenotype associations to identify genetic markers, enhancing our understanding of LN pathogenesis. This study used genotype-phenotype association to explore genetic variants linked to LN in a Taiwanese cohort from the Taiwan Precision Medicine Initiative (TPMI). Genotyping was performed on 244 SLE and 63 LN patients using the TPM array. Genomic DNA underwent quality control via the Axiom Analysis Suite. Chi-squared tests identified significant variants, which were annotated and assessed for functional impacts using the 1000 Genomes Project, gnomAD, enabling comprehensive genetic analysis. This study on a Taiwanese cohort (LN, SLE, LN/SLE) identified four significant genetic variants (p-values < 10

Indexed as

Genetic Predisposition to DiseaseLupus NephritisPolymorphism, Single NucleotideAdultCohort StudiesFemaleGenetic Association StudiesGenetic TestingGenotypeHumansMaleMiddle AgedTaiwan

Identifiers

PMID41073606
PMCPMC12514177

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