Evidence map›Paper›PMID 41073552›Full record

ArticleOncogene2025

Comprehensive single-cell analysis reveals mast cells' roles in cancer immunity.

Hao Qian, Wenbo Wang, Jiaomeng Pan, Ming Zhao, Li Gao, Jia Zeng, Hang Gong, Guangyan Zhangyuan, Zi Li, Mao Zhang and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Developments in Mast Cell Research.The Journal of allergy and clinical immunology · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hao Qian *Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID 0000-0001-6578-1563
Wenbo Wang *Department of Orthopedic Surgery, Shanghai Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiaomeng Pan *Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.
Ming Zhao *Yu-Yue Pathology Scientific Research Center, Chongqing, China.ORCID 0009-0007-3559-4901
Li GaoCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Jia ZengDepartment of Urology, Hunan University of Medicine General Hospital, Huaihua, Hunan, China.
Hang GongDepartment of Hepatobiliary Surgery, Hunan University of Medicine General Hospital, Huaihua, Hunan, China.
Guangyan ZhangyuanDepartment of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zi LiCAS Key Laboratory of Nutrition, Metabolism, and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS), Shanghai, China.
Mao ZhangDepartment of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.
Xia ShenCenter for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xiashen@sjtu.edu.cn.ORCID 0000-0002-3711-2028
Yuanchi WengDepartment of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. wyuanchi@126.com.ORCID 0000-0003-2808-6240
Xiaxing DengDepartment of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. kejiadxx@hotmail.com.ORCID 0000-0003-1565-4229
Yingying HuangCenter for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China. huangyingying@fudan.edu.cn.ORCID 0009-0007-0383-2469

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mast cells, traditionally known for their roles in allergic reactions and pathogen defense, have been revealed to possess significant functional diversity within the tumor microenvironment (TME). Through single-cell RNA sequencing analysis across 15 solid tumors (385 samples from 264 patients), 10 distinct mast cell states characterized by unique gene expression patterns and functional attributes were identified. Notably, the C7-HLA-DR cluster that closely linked with antigen presentation, has emerged as a key player in shaping anti-tumor immune responses. In this study, systematic analysis demonstrated that the C7-HLA-DR cluster could interact with T cells to enhance the efficacy of immunotherapy and improve patients' prognosis. On the contrary, the C1-HSPA1 cluster exhibited pro-tumor characteristics, highlighting the functional diversity of mast cells within TME. These findings illustrate the landscape of mast cell within TME and propose a new avenue to boost the efficacy of immunotherapy.

Indexed as

Mast CellsNeoplasmsSingle-Cell AnalysisHLA-DR AntigensHumansImmunotherapyPrognosisT-LymphocytesTumor MicroenvironmentHLA-DR Antigens

Identifiers

PMID41073552

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.