Evidence map›Paper›PMID 41073539›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Methylation profiling: a diagnostic tool for the diagnosis of Merkel cell carcinoma of the lymph node without detectable skin primary tumor.

Paul-Louis Chantreau, Pierre Sohier, Mahtab Samimi, Matthias Tallegas, Anne Tallet, Serge Guyetant, Benjamin Goeppert, Maysa Al-Hussaini, Ferdinand Toberer, Nathalia Giese and 3 more

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Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Paul-Louis ChantreauDepartment of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, 37044, Tours, France.
Pierre SohierDepartment of Pathology, AP-HP, Faculté de Médecine Paris Centre Santé, Hopital Cochin, University of Paris, Paris, France.
Mahtab SamimiCARADERM Network, Pau, France.
Matthias TallegasDepartment of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, 37044, Tours, France.
Anne TalletPlatform of Somatic Tumor Molecular Genetics,, Université de Tours, Centre Hospitalier Universitaire de Tours,, 37044, Tours, France.
Serge GuyetantDepartment of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, 37044, Tours, France.
Benjamin GoeppertInstitute of Pathology and Neuropathology, RKH Kliniken Ludwigsburg, Ludwigsburg, Germany.
Maysa Al-HussainiDepartment of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan.
Ferdinand TobererDepartment of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany.
Nathalia GieseDepartment of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany.
Stéphanie RoesslerDepartment of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany.
Andreas von DeimlingDepartment of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany.
Thibault KervarrecDepartment of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, 37044, Tours, France. thibaultkervarrec@yahoo.fr.ORCID http://orcid.org/0000-0002-2201-6914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is an aggressive tumor mostly related to Merkel cell polyomavirus genomic integration. MCC can present either as a primary cutaneous tumor or as a lymph node metastasis without a primary skin tumor (MCCWOPT). The distinction between MCCWOPT and lymph node metastases of non-cutaneous neuroendocrine carcinomas remains challenging. The present study aims to determine whether the methylation profile can distinguish MCCWOPT from lymph node metastases of extracutaneous neuroendocrine carcinomas. Methylation profiles of twenty MCCWOPT were compared to 23 cutaneous MCC, 37 small-cell lung carcinomas, 17 and 34 well-differentiated neuroendocrine tumors of the ileum and pancreas. Among the controls, cutaneous MCC cases formed a cluster distinct from other extracutaneous neuroendocrine tumors. MCCWOPT clustered together with cutaneous MCC cases. Methylation profiling represents a promising additional tool for the diagnosis of MCCWOPT.

Indexed as

Biomarkers, TumorCarcinoma, Merkel CellDNA MethylationLymph NodesSkin NeoplasmsAgedAged, 80 and overDiagnosis, DifferentialFemaleHumansLymphatic MetastasisMaleMiddle AgedBiomarkers, TumorDifferential diagnosisLymph nodesMCPyVMerkel cell carcinomaMetastasisMethylation profilingNeuroendocrine carcinoma

Identifiers

PMID41073539

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.