Evidence map›Paper›PMID 41073470›Full record

ArticleScientific reports2025

Sequential addition synthesis of guar gum based ternary hydrogels with kinetic asymmetry in drug release.

Ambreen Ghani, Muhammad Atif, Sahar Saleem, Musinguzi Alex, Erum Akbar Hussain, Mohammed Ali Assiri, Muhammad Asad Faroqui

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ambreen GhaniDepartment of Chemistry, University of Education Lahore (Vehari Campus), Vehari, Pakistan.
Muhammad AtifDepartment of Chemistry, University of Education Lahore (Vehari Campus), Vehari, Pakistan.
Sahar SaleemDepartment of Chemistry, University of Education Lahore (Vehari Campus), Vehari, Pakistan.
Musinguzi AlexDepartment of Polymer, Textile and Industrial Engineering, Busitema University (Main Campus), P.O. Box 236, Tororo, Uganda. malex.eng@busitema.ac.ug.
Erum Akbar HussainDepartment of Chemistry, Lahore College for Women University, Lahore, Pakistan.
Mohammed Ali AssiriChemistry Department, Faculty of Science, King Khalid University, P.O. Box 9004, 61413, Abha, Saudi Arabia.
Muhammad Asad FaroquiDepartment of Chemistry, University of Education Lahore (Vehari Campus), Vehari, Pakistan.

Funding

Deanship of Scientific Research at King Khalid University, Saudi Arabia RGP-2/524/44
6 · The paper itself

Abstract

Currently, biomedical engineering is placing significant emphasis on hydrogels due to their exceptional capabilities in drug delivery, tissue regeneration, tissue adhesion, blood clot prevention, contrast imaging, safeguarding tissues or organs during radiotherapy, and enhancing the biocompatibility of medical implants. This study explores a temperature-controlled sequential addition method to synthesize pH responsive guar gum-sodium alginate hydrogels with PVA as third component. Obtained hydrogels have been observed with kinetic asymmetry in drug release at specific pH. The sequential addition method has augmented thermal stability of products by allowing for distinct crosslinking patterns in the hydrogels produced. Kinetic assymetry of in-vitro drug release has been observed, specifically depending upon drug hydrogel interaction as hydrogen bonding. The blends that were prepared with higher sodium alginate (NaA) contents demonstrated 1st order drug release kinetics due to highest swelling and fast ionic dissociation leads to fast drug release, whereas samples with higher guargum (GG) ratio in compositions presented zero order kinetics due to compact structure and sustained swelling. The maximum drug release achieved within 12 h was 92% in intestine at 7.4 (colon pH), which was subsequently characterized by non-Fickian diffusion due to polymer relaxation.

Indexed as

Drug CarriersDrug LiberationGalactansHydrogelsMannansPlant GumsAlginatesDrug Delivery SystemsHydrogen-Ion ConcentrationKineticsPolyvinyl AlcoholTemperatureAlginatesDrug CarriersGalactansguar gumHydrogelsMannansPlant GumsPolyvinyl AlcoholControlled releaseDiffusionDrug deliverypH stimulated hydrogelsProcessing optimization

Identifiers

PMID41073470
PMCPMC12514208

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.