Observational studyScientific reports2025
Impact of selenium status and supplementation on outcomes in critically ill patients.
Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenium is an essential trace element involved in antioxidant defense and immune regulation, yet its clinical role in critically ill patients remains uncertain. In this prospective single-center observational study, we evaluated 144 ICU patients between March 2022 and October 2023. Serum selenium levels were measured, and eligible patients received intravenous selenium supplementation (1000 µg/day for 5 days). Clinical outcomes, including ICU mortality, were analyzed in relation to selenium status and response. Selenium levels < 70 µg/L were observed in 27.8% of patients and were associated with higher severity scores, inflammatory markers, and longer hospital stay. Among 67 patients receiving supplementation, those with a post-treatment selenium increase > 50 µg/L had significantly lower ICU mortality. Multivariate analysis identified SOFA score, FiO
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