Evidence map›Paper›PMID 41073454›Full record

ArticleScientific reports2025

Profile of the BREATHE cohort for risk-based breast screening in Singapore.

Peh Joo Ho, Jenny Liu, Su-Ann Goh, Alexis Jiaying Khng, Nur Khaliesah Mohamed Riza, Ying Jia Chew, Desmond Luan Seng Ong, Yi Wang, Fook Ming Hew, Pooja Jagmohan and 14 more

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Peh Joo Ho *Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Jenny Liu *Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Su-Ann GohDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, 119228, Singapore.
Alexis Jiaying KhngGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Singapore, 138672, Singapore.
Nur Khaliesah Mohamed RizaSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Ying Jia ChewDepartment of Surgery, National University Hospital and National University Health System, Singapore, 119228, Singapore.
Desmond Luan Seng OngJurong Polyclinic, National University Polyclinics and National University Health System, Singapore, 609788, Singapore.
Yi WangSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Fook Ming HewSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Pooja JagmohanDepartment of Diagnostic Imaging, National University Hospital and National University Health System, Singapore, 119074, Singapore.
Premilla Gopinathan PillayDepartment of Diagnostic Imaging, National University Hospital and National University Health System, Singapore, 119074, Singapore.
Yonggeng GohDepartment of Diagnostic Imaging, National University Hospital and National University Health System, Singapore, 119074, Singapore.
Han Yang OngDepartment of Diagnostic Imaging, National University Hospital and National University Health System, Singapore, 119074, Singapore.
Abrar Mohammed AlsunbulDepartment of Diagnostic Imaging, National University Hospital and National University Health System, Singapore, 119074, Singapore.
Han Boon OhDepartment of General Surgery, Ng Teng Fong General Hospital, Singapore, 609606, Singapore.
Christopher Hang Liang KehDepartment of General Surgery, Ng Teng Fong General Hospital, Singapore, 609606, Singapore.
Chi Hui ChinJurong Polyclinic, National University Polyclinics and National University Health System, Singapore, 609788, Singapore.
Sing Cheer KwekBukit Batok Polyclinic, National University Polyclinics and National University Health System, Singapore, 659164, Singapore.
Zhi Peng ZhangChoa Chu Kang Polyclinic, National University Polyclinics and National University Health System, Singapore, 688846, Singapore.
Swee Tian QuekDepartment of Diagnostic Imaging, National University Hospital and National University Health System, Singapore, 119074, Singapore.
Sujith WijerathneDepartment of Surgery, National University Hospital and National University Health System, Singapore, 119228, Singapore.
Jingmei Li *Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Singapore, 138672, Singapore.
Philip Choong Tsau Iau *Department of General Surgery, Ng Teng Fong General Hospital, Singapore, 609606, Singapore.
Mikael Hartman *Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore. mikael_hartman@nuhs.edu.sg.

Funding

Breast Cancer Prevention Programme under Saw Swee Hock School of Public Health Programme of Research Seed Funding SSHSPH-Res-Prog-BCPPBreast Cancer Screening Prevention Programme under Yong Loo Lin School of Medicine NUHSRO/2020/121/BCSPP/LOAJurongHealth Fund JHF-20-RE-003National Research Foundation, Singapore, Precision Health Research Singapore under its Clinical Implementation Pilot Fund PRECISE CIPNational University Cancer Institute Singapore (NCIS) Centre Grant Programme CGAug16M005
6 · The paper itself

Abstract

The BREAst screening Tailored for HEr (BREATHE) study was established to pilot a personalised, risk-based breast cancer screening programme for a multi-ethnic Asian population. Between October 2021 and December 2023, 4592 women aged 35-59 were enrolled (73% response rate). Follow-up from February 2022 to June 2024 included 4112 participants (8.6% loss to follow-up). Data collected encompassed demographics, lifestyle factors, reproductive risks, breast cancer awareness, screening behaviours, programme satisfaction, mammography outcomes (density and recall status), and genotype data. Above-average breast cancer risk increased with age: 2% in women aged 35-39, 31% in 40-49, and 42% in 50-59. Findings suggests that women valued the knowledge of their breast cancer risk and were motivated to attend mammography. The BREATHE study confirms the feasibility and acceptability of a personalised risk-based screening programme in a multi-ethnic Asian population, highlighting the value of tailored protocols to improve early detection and outcomes. Further details are available in the study protocol and online at https://blog.nus.edu.sg/breathe/ .

Indexed as

Breast NeoplasmsEarly Detection of CancerAdultCohort StudiesFemaleHumansMammographyMass ScreeningMiddle AgedPilot ProjectsRisk FactorsSingaporeBreast densityEarly detection of cancerGenetic risk scoreMammographyRisk assessment

Identifiers

PMID41073454
PMCPMC12514159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.