Evidence map›Paper›PMID 41073435›Full record

ArticleNature communications2025

LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan.

Soumya Joseph, Nicholas J Schnicker, Nicholas Spellmon, Zhen Xu, Rui Yan, Zhiheng Yu, Omar Davulcu, Tiandi Yang, Jesse Hopkins, Mary E Anderson and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Soumya JosephSenator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-0487-1378
Nicholas J SchnickerDepartment of Molecular Physiology and Biophysics, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-5189-4943
Nicholas SpellmonJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-2045-1373
Zhen XuProtein and Crystallography Facility, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-8855-0565
Rui YanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-0167-2816
Zhiheng YuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-7114-2570
Omar DavulcuPacific Northwest National Laboratory, Environmental Molecular Sciences Laboratory, Richland, WA, USA.ORCID http://orcid.org/0000-0002-7056-6435
Tiandi YangSenator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-6634-0847
Jesse HopkinsBioCAT Beamline 18-ID-D, Advanced Photon Source, Argonne National Laboratory, Lemont, IL, USA.ORCID http://orcid.org/0000-0001-8554-8072
Mary E AndersonSenator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA.
David VenzkeSenator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-8180-9562
Kevin P CampbellSenator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA. kevin-campbell@uiowa.edu.ORCID http://orcid.org/0000-0003-2066-5889

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Therapeutic Potential of ESC-Derived Myogenic PrecursorsU54NS053672 · NINDS · UNIVERSITY OF IOWA · PI CAMPBELL, KEVIN P. · 2005 to 2019
$22.0M
Pacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5M
The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
Muscular Dystrophy Specialized Research Center: Project 2P50NS053672 · NINDS · UNIVERSITY OF IOWA · PI KEVIN P. CAMPBELL · 2020 to 2026
$11.9M
Time resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9M
Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber DiffractionS10OD018090 · OD · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2014 to 2014
$529k
NIGMS NIH HHS P30 GM138395NIGMS NIH HHS P41 GM103622NIGMS NIH HHS R24 GM154185NIGMS NIH HHS U24 GM129547NIH HHS S10 OD018090NINDS NIH HHS P50 NS053672NINDS NIH HHS U54 NS053672
6 · The paper itself

Abstract

Matriglycan is a linear glycan (xylose-β1,3-glucuronate)

Indexed as

DystroglycansN-AcetylglucosaminyltransferasesPolysaccharidesAnimalsCatalytic DomainCryoelectron MicroscopyHumansPolymerizationDystroglycansLARGE1 protein, humanN-AcetylglucosaminyltransferasesPolysaccharides

Identifiers

PMID41073435
PMCPMC12514197

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.