ArticleNature communications2025
HAND2 invades nucleolar condensates to pioneer lineage-specific cardiac pacemaker gene programs.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Epithelial sensing of vitamin A shapes intestinal antimicrobial defense.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
9 authors.
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Abstract
Although best known as the site for ribosome assembly, the nucleolus organizes heterochromatin into transcriptionally repressed Nucleolus-Associated Domains (NADs). NADs harbor many genes involved in cell-type specification, yet the mechanisms by which transcription factors (TFs) access this heterochromatin to activate gene expression remain unknown. Using a model of TF-induced cardiac pacemaker reprogramming, we conclusively establish that nucleolar localization of HAND2 is required for successful lineage conversion. Moreover, we perform unbiased transcriptional profiling to demonstrate that pacemaker gene programs are highly compartmentalized within the nucleus. Finally, we show that HAND2 homodimers invade nucleolar condensates and concentrate within the nucleolus to bind palindromic motifs required for activating lineage-specific enhancers buried within NADs. Taken together, our data highlight a key role for the nucleolus in orchestrating pacemaker gene expression by HAND2. More broadly, these results suggest that TF localization to sub-nuclear heterochromatin domains may represent a potent strategy for activating lineage-specific gene programs.
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