SynthesisTranslational psychiatry2025
The translational potential of salvinorin A: systematic review and meta-analysis of preclinical studies.
Synthesis in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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5 authors.
Funding
Abstract
backgroundSalvinorin A, the main psychoactive compound of Salvia divinorum, is a potent and selective kappa opioid receptor agonist. While human clinical trials remain limited, animal studies suggest potential therapeutic applications in neurological and psychiatric disorders. This systematic review and meta-analysis aims to synthesize these preclinical findings, addressing three questions: (1) What is the therapeutic potential of salvinorin A in animal models of neurological and psychiatric disorders? (2) What are its toxic effects on behaviour, cognition, and physiological function? (3) What are its pharmacokinetic characteristics?
methodsA systematic search of Medline, Web of Science, and EMBASE for studies published up to June 28, 2024, identified 1718 publications, of which 82 were included in the qualitative synthesis and 10 in the meta-analysis.
resultsSalvinorin A has been tested in animal models of pain, cerebrovascular insults, addiction, and depression. It exhibited anti-nociceptive, anti-inflammatory, neuroprotective, and anti-addictive effects. Findings on depression were inconsistent, with both antidepressant and depressogenic outcomes reported. Toxicity data indicate anxiogenic effects and motor and cognitive impairment, with minimal impact on vital parameters. Applied doses ranged from 0.1-10 mg/kg, with lower doses in stroke models. Pharmacokinetic data show rapid onset, fast peak, and a half-life of approximately one hour. Sixteen structurally distinct salvinorin A analogues were identified with potentially improved safety and pharmacokinetic profiles.
conclusionOur findings support the therapeutic potential of salvinorin A for pain, addiction, and stroke, though its side effect profile may limit clinical application. The development of novel analogues could address these challenges.
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