Evidence map›Paper›PMID 41073396›Full record

ArticleNature communications2025

Two complementary NLRs from wild emmer wheat confer powdery mildew resistance.

Zuhuan Yang, Nannan Liu, Xiaoming Xie, Wenxin Wei, Yuhan Bai, Junna Sun, Wei Pan, Jiatian Yang, Weidong Wang, Xiaodong Xie and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The Auxin Response FactorPlants (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Zuhuan YangState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.ORCID http://orcid.org/0009-0009-1787-6192
Nannan LiuState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.
Xiaoming XieState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-7925-4964
Wenxin WeiState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.
Yuhan BaiCollege of Life Sciences, Capital Normal University, Beijing, China.
Junna SunState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.
Wei PanState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.
Jiatian YangState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.
Weidong WangState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.
Xiaodong XieTianjin Key Laboratory of Intelligent Breeding of Major Crops/International Joint Center for the Mechanismic Dissection and Genetic Improvement of Crop Stress Tolerance, College of Agriculture & Resources and Environmental Sciences, Tianjin Agricultural University, Tianjin, China.
Muhammad SaqlainTriticeae Research Institute, Sichuan Agricultural University, Chengdu, China.
Houyang KangTriticeae Research Institute, Sichuan Agricultural University, Chengdu, China.
Baoyun LiState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-6794-1150
Zhaorong HuState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-1815-648X
Jinying GouState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-7540-0354
Weilong GuoState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0001-5199-1359
Susheng SongCollege of Life Sciences, Capital Normal University, Beijing, China.
Jun MaState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.
Tzion FahimaInstitute of Evolution, University of Haifa, Mt, Carmel, Israel.
Qixin SunState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-3819-6892
Lina QiuTianjin Key Laboratory of Intelligent Breeding of Major Crops/International Joint Center for the Mechanismic Dissection and Genetic Improvement of Crop Stress Tolerance, College of Agriculture & Resources and Environmental Sciences, Tianjin Agricultural University, Tianjin, China. qiulina@tjau.edu.cn.ORCID http://orcid.org/0009-0006-9393-2764
Yinghui LiTriticeae Research Institute, Sichuan Agricultural University, Chengdu, China. liyinghui@sicau.edu.cn.ORCID http://orcid.org/0000-0001-9271-4112
Chaojie XieState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, China. xiecj127@126.com.ORCID http://orcid.org/0000-0001-6955-3330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Powdery mildew is a devastating disease that affects wheat yield and quality globally. Here, we identify a powdery mildew resistance locus MlIW39 from wild emmer wheat through map-based cloning, mutagenesis, and stable genetic transformation. Unlike many other cloned Pm genes, the MlIW39-mediated resistance is conferred by the combined effect of two complementary nucleotide-binding and leucine-rich repeat (NLR) genes, encoding a canonical coiled-coil (CC) type NLR protein (MlIW39-R1) and an atypical NLR protein (MlIW39-R2) with an unknown domain (CC-like), respectively. Overexpression of the NLR pair induces cell death in Nicotiana benthamiana, whereas MlIW39-R1 or MlIW39-R2 alone does not. The MlIW39-R1 and MlIW39-R2 proteins physically interact with each other. MlIW39-R1 and MlIW39-R2 likely originate independently and become neighborly located during evolution. Our findings shed light on the significance of NLR pairs in plant immunity and can facilitate wheat disease-resistance breeding using the developed MlIW39 introgression lines and functional marker.

Indexed as

AscomycotaDisease ResistanceNLR ProteinsPlant DiseasesPlant ProteinsTriticumGene Expression Regulation, PlantNicotianaPlants, Genetically ModifiedNLR ProteinsPlant Proteins

Identifiers

PMID41073396
PMCPMC12514233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.