Observational studyOpen heart2025
Association between atherogenic index of plasma and incident aortic disease: a population-based prospective analysis.
Observational study in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo clarify whether atherogenic index of plasma (AIP), a comprehensive indicator reflecting both the protective and atherogenic effects of lipoproteins on cardiometabolic health, is associated with increased risk of aortic disease.
designLarge-scale, population-based, observational, prospective cohort study. DATA SOURCES: Health dataset from UK Biobank.
participantsA total of 17 530 participants, aged 40-70 years, were enrolled and completed the initial assessment visit before 2010. Participants with a history of aortic dissection (AD) or aortic aneurysm (AA), baseline connective tissue disease, missing triglyceride and high-density lipoprotein cholesterol values, fasting time less than 8 hours or those lost to follow-up were excluded.
main outcome measuresAortic disease, a composite outcome comprising AD and AA.
resultsDuring a median follow-up period of 15.1 years, 164 aortic disease cases, including 14 AD and 155 AA cases, were documented. A linear trend between AIP and the risk of incident aortic disease was confirmed (p for non-linear=0.134). The multivariable-adjusted incident risk of aortic disease gradually increased with elevated AIP tertiles (adjusted HR (aHR) 1.0 (reference) in tertile 1, aHR 1.48 (95% CI 0.91 to 2.41) in tertile 2, aHR 2.04 (95% CI 1.26 to 3.29) in tertile 3), following an adjustment for age, sex, smoking status, drinking status, body mass index, hypertension, low-density lipoprotein cholesterol and glycated haemoglobin. Specifically, participants in the highest AIP tertile had the highest incident risk of AA, with an aHR of 2.47 (95% CI 1.47 to 4.16).
conclusionsAIP is significantly associated with a higher risk of incident aortic disease, indicating that AIP is an effective risk assessment method for aortic disease, especially for AA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.