Successful Management of Oxacillin-Induced Eosinophilic Myocarditis and Review of the Literature.

Arnold Gan, Morgan Burke, Eric Yang, Tiffany Lien, Khalida Arif, Maxine Stachel

Abstract readCase Reports

In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arnold GanUSC/Los Angeles General Medical Center, Los Angeles, California, USA. Electronic address: Gan.Arnold95@gmail.com.

Morgan BurkeUSC/Los Angeles General Medical Center, Los Angeles, California, USA.

Eric YangKeck School of Medicine of USC, Los Angeles, California, USA.

Tiffany LienUSC/Los Angeles General Medical Center, Los Angeles, California, USA.

Khalida ArifUSC/Los Angeles General Medical Center, Los Angeles, California, USA.

Maxine StachelDivision of Cardiology, Keck Medicine of USC, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous medications have been implicated in precipitating eosinophilic myocarditis (EM), particularly antipsychotics and cytotoxic drugs. Antibiotic-induced EM, scarcely reported in the literature, carries a high mortality rate. CASE SUMMARY: A 56-year-old man with a history of atypical hemolytic uremic syndrome presented with acute heart failure after completing oxacillin treatment for methicillin-susceptible Staphylococcus aureus bacteremia. Diagnosis of antibiotic-induced EM was established with endomyocardial biopsy, and the patient made full recovery with high-dose steroid treatment. REVIEW SUMMARY: Prompt diagnosis and early steroid treatment is essential in reducing mortality in patients with antibiotic-induced EM. Multidisciplinary discussion is vital, and development of clinical scoring criteria to identify high-risk patients may assist clinicians in pursuing early endomyocardial biopsy to expedite diagnosis. TAKE-HOME MESSAGE: Antibiotic-induced EM is exceedingly rare but should be suspected when acute heart failure is associated with systemic inflammatory symptoms.

Indexed as

drug reaction with eosinophilia and systemic symptomseosinophilic myocarditishypersensitivity myocarditismyocarditisoxacillin

Identifiers

PMID41072989

DOI10.1016/j.jaccas.2025.105297

PMCPMC12516267

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