ArticleJACC. Case reports2025
Coronary Microvascular Dysfunction Related to Hydroxychloroquine-Induced Cardiomyopathy.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
backgroundA 69-year-old woman with seropositive rheumatoid arthritis presented with subacute worsening of her chronic chest pain. CASE SUMMARY: Cardiac magnetic resonance demonstrated new diffuse edema, patchy late gadolinium enhancement, and a reduction in myocardial perfusion reserve index, which raised concern for an infiltrative cardiomyopathy leading to microvascular dysfunction. An endomyocardial biopsy resulted in a rare diagnosis of drug-induced cardiomyopathy. DISCUSSION: We report a new association between this drug toxicity and coronary microvascular disease. This represents not only a new finding but potential expanded understanding of the pathophysiology of this disease condition. This finding could have implications for both diagnostic testing and disease management. TAKE-HOME MESSAGES: This case establishes a new relationship between hydroxychloroquine cardiomyopathy and microvascular dysfunction. In addition to the cytotoxic effects of hydroxychloroquine, there may be an additional mechanism of vascular injury leading to the known manifestations with various electrical disturbances, and myocardial dysfunction.
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