ArticleJACC. Case reports2025
Paradoxical Embolism Leading to Myocardial Infarction: Revisiting the Significance of Patent Foramen Ovale.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatent foramen ovale (PFO) is a common anatomic defect, present in about 14% to 35% of the general population. Its clinical significance and management remain unclear in the context of new-onset strokes. CASE SUMMARY: An 80-year-old woman presented with arm heaviness and calf pain. She was diagnosed with venous, arterial thrombi and type 1 non-ST-segment elevation acute coronary syndrome due to a paradoxical embolus via a PFO, which was medically managed without closure. DISCUSSION: Current guidelines, based on limited data, provide conditional recommendations for PFO closure in the presence of systemic embolism without a stroke. The decision to medically manage or close a PFO requires further study and should involve shared decision-making. TAKE-HOME MESSAGES: A high index of suspicion is required to diagnosis PFO-mediated paradoxical emboli. Isolated, distal culprit coronary lesions warrant work-up for nonatherosclerotic causes of myocardial infarction.
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