ArticleStem cell reports2025
Human iPSC-derived salivary gland cell sheets integrate with injured glands to form glandular structures.
Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Stem cell transplantation in head and neck oncology: Integrating oncologic treatment and maxillofacial reconstruction.World journal of transplantation · 2026Review
- A Narrative Review of Salivary Gland Extracellular Matrix and Sjögren's Syndrome: Research Status and Future Prospects.Biomolecules · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional integration of transplanted cells with host tissue remains a major challenge in cell-based therapies for tissue damage in organs with complex structures, such as exocrine glands. In this study, we investigated whether salivary gland organoids derived from human induced pluripotent stem cells (hiPSCs) could be integrated into injured salivary glands using cell sheet engineering. Cell sheet engineering has demonstrated therapeutic potential in a range of organs, including the heart, retina, and lungs. We found that hiPSC-derived salivary gland organoids contain long-term maintainable progenitor cells, and the resulting cell sheets exhibited heterogeneity, including acinar, ductal, and myoepithelial cells. Furthermore, transplantation of the organoid-derived salivary gland cell sheets into immunodeficient mice resulted in partial integration with the host salivary ducts, leading to the formation of structures that included xenogeneic chimeric ducts. These findings suggest that salivary gland cell sheet transplantation represents a promising strategy for functional salivary gland regeneration.
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