Trial reportThe Journal of infectious diseases2026
Immune Responses to BK Virus in Renal Transplant Recipients Receiving Intravenous Immunoglobulin Treatment.
Trial report in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02659891 (Immunoglobulin), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immunoglobulin (Privigen®) Therapy to Treat BK Viremia and Prevent Alloimmune Activation in Kidney Transplant Recipients
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundBK polyomavirus (BKPyV) DNAemia in renal transplant recipients increases risk of allograft failure, but BKPyV-specific therapies are not available. While treatment with intravenous immunoglobulin (IVIG) has been reported, safety in a prospective randomized controlled setting is uncertain, and host immune response to BKPyV after IVIG is not well characterized.
methodsWe investigated host immune responses to BKPyV in a multicenter, prospective, randomized, double-blinded, placebo-controlled pilot study of IVIG with protocolized immunosuppression reduction in adult kidney transplant recipients with BK DNAemia. Participants received 2 infusions of 1 g/kg up to 70 g each, 1 month apart, of IVIG or placebo and were followed for 1 year with adverse event monitoring. The primary endpoint was safety and tolerability of IVIG. Neutralizing antibody (nAb) to common BKPyV strains and BK-specific CD4+/CD8+ T-cell and natural killer cell responses were evaluated.
resultsThere were no adverse events. Forty percent of recipients in the treatment arm and 44.4% in the control arm cleared BK DNAemia at 3 months (relative risk, 0.90 [95% confidence interval, .23-2.89]). Overall, 80% of recipients with a sequenced BK genotype possessed cognate nAbs at baseline, and 100% acquired them by 3 months. Viral clearance was associated with higher percentages of BKPyV-specific CD8+ T cells prior to IVIG treatment (0.19% vs 3.01%; P < .01).
conclusionsIn this pilot study, treatment with 2 doses of IVIG was safe, but its impact on viral clearance is unclear. Control of DNAemia may depend upon intrinsic virus-specific host cellular and humoral response, but further studies are needed. CLINICAL TRIALS REGISTRATION: NCT02659891.
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