ArticleScience advances2025
Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches.
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Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
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Who cites it
4 citing papers in PubMed.
- Adipose Tissue Palmitoylation Cycling Mediates Insulin Resistance and Preservation of β-Cell Function in Mice.Diabetes · 2026Article
- The central role of the β-cell in diabetes: from monogenic forms to type 1, type 2, and gestational diabetes.Reviews in endocrine & metabolic disorders · 2026Review
- From pancreas and islet resources to diabetes insights.Diabetologia · 2026Review
- Mitochondria as Epigenetic Regulators of β-Cell Identity and Plasticity: A Metabolo-Epigenetic Perspective.Cells · 2026Review
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Authors and funding
41 authors.
Mara SuleimanDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0002-2478-8782
Toshiaki SawataniULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0001-6714-6221
Marta TesiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0001-6451-9053
Xiaoyan YiULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0001-6995-8573
Theodora PapadopoulouULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0009-0006-0172-7932
Chantal RuferULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0002-7314-6364
Maria LytriviULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.
Emanuele BosiDepartment of Earth, Environmental and Life Sciences (DISTAV), University of Genova, Genova, Italy.ORCID 0000-0002-4769-8667
Frederic BurdetVital-IT Group, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.ORCID 0000-0002-2923-827X
Federica FantuzziULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0003-3202-3947
Carmela De LucaDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Guido SebastianiDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.ORCID 0000-0003-4374-8564
Chiara SaponaroDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0001-7336-7362
Licia Anna PuglieseNEST Laboratory, Scuola Normale Superiore, Pisa, Italy.
Silvia Del GuerraDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Alessandro PocaiJohnson &Johnson Innovative Medicine, Cardiovascular & Metabolism, Philadelphia, PA, USA.ORCID 0000-0003-1450-9521
Paolo De SimoneDepartment of Surgical, Medical, Biochemical Pathology and Intensive Care, University of Pisa, Pisa, Italy.
Davide GhinolfiHepatobiliary Surgery and Liver Transplantation Unit, University Hospital, Pisa, Italy.
Ugo BoggiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.ORCID 0000-0002-7505-5896
Camille KesslerVital-IT Group, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.ORCID 0000-0003-2871-5625
Giuseppina Emanuela GriecoDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.ORCID 0000-0001-7325-6128
Daniela FignaniDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.ORCID 0000-0001-8803-5846
Julie Kerr-ConteUniversity of Lille, Inserm, Institut Pasteur Lille, CHU Lille, European Genomic Institute for Diabetes, UMR 1190 Translational Research for Diabetes, Lille, France.ORCID 0000-0002-7590-1896
François PattouUniversity of Lille, Inserm, Institut Pasteur Lille, CHU Lille, European Genomic Institute for Diabetes, UMR 1190 Translational Research for Diabetes, Lille, France.ORCID 0000-0001-8388-3766
Montserrat NacherHospital Universitarie Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and University of Barcelona, Barcelona, Spain.ORCID 0000-0002-8458-9275
Eduard MontanyaHospital Universitarie Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and University of Barcelona, Barcelona, Spain.ORCID 0000-0003-2518-9076
Nizar MouradPôle de chirurgie expérimentale et transplantation, Institut de recherche expérimentale et clinique, Université catholique de Louvain, Brussels, Belgium.ORCID 0000-0003-2472-2780
Antoine BuemiPôle de chirurgie expérimentale et transplantation, Institut de recherche expérimentale et clinique, Université catholique de Louvain, Brussels, Belgium.ORCID 0000-0001-9341-7902
Valentina CitiDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Alma MartelliDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID 0000-0002-2090-7107
Giada BenedettiDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Vincenzo CalderoneDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID 0000-0002-1441-5421
Leonardo RossiGenetic Biology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Aldo PaolicchiClinical Pathology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.ORCID 0000-0002-9940-8481
Francesco CardarelliNEST Laboratory, Scuola Normale Superiore, Pisa, Italy.
Francesco DottaDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.ORCID 0000-0003-4947-7478
Decio L EizirikULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0003-2453-5889
Mark IbbersonVital-IT Group, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.ORCID 0000-0003-3152-5670
Piero MarchettiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0003-4907-0635
Miriam CnopULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0002-5112-1692
Lorella MarselliClinical Pathology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.ORCID 0000-0002-6698-2962
Funding
The Integrated Stress Response in Human Islets During Early T1DU01DK127786 · NIDDK · UNIVERSITY OF CHICAGO · PI EVANS-MOLINA, CARMELLA, MIRMIRA, RAGHAVENDRA G · 2020 to 2025
$7.1MImplications of Changes in Islet Exosomal Cargo in Type 1 DiabetesR01DK133881 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA, MIRMIRA, RAGHAVENDRA G · 2022 to 2025
$2.7MiPLA2beta-mediated alternative splicing and -cell death in type 1 diabetesR01DK126444 · NIDDK · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E., EIZIRIK, DECIO LAKS · 2021 to 2024
$2.0MNIDDK NIH HHS R01 DK126444NIDDK NIH HHS R01 DK133881NIDDK NIH HHS U01 DK127786
Abstract
Remission of type 2 diabetes (T2D) can occur after hypocaloric diet, bariatric surgery, or pharmacological treatments and associates with improved β cell function. Here, we studied islets from nondiabetic (
Indexed as
Diabetes Mellitus, Type 2Insulin-Secreting CellsTranscriptomeAnimalsFemaleGene Expression ProfilingGlucoseHumansMaleMiceMiddle AgedGlucose
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