Evidence map›Paper›PMID 41071782›Full record

Trial reportPloS one2025

Generalized estimating equations for modeling cluster randomized trial data on smoking cessation among tuberculosis patients.

Vasantha Mahalingam, Ratnakar Singh, Ramesh Kumar Santhanakrishnan, Adhin Bhaskar, Ponnuraja Chinnaiyan

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vasantha MahalingamDepartment of Statistics, ICMR-National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.ORCID https://orcid.org/0000-0003-0390-346X
Ratnakar SinghDepartment of Statistics, ICMR-National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.ORCID https://orcid.org/0009-0006-9040-4659
Ramesh Kumar SanthanakrishnanDepartment of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.
Adhin BhaskarDepartment of Statistics, ICMR-National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.
Ponnuraja ChinnaiyanDepartment of Statistics, ICMR-National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.ORCID https://orcid.org/0000-0003-1762-6424

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a paucity of studies applying Generalized Estimating Equations (GEE) for longitudinal analysis of smoking cessation outcomes within the framework of a cluster randomized trial, especially among tuberculosis (TB) patients. In this study, a GEE model which accounts for repeated measures and cluster-level effects was implemented to identify factors associated with smoking cessation among TB patients. The data included 375 TB patients who were smokers and given TB treatment during 2013-2016 in Kanchipuram and Villupuram districts under a cluster randomized trial. GEE modeling provided robust, population-averaged estimates while accounting for intra-cluster correlation, confirming the sustained impact of these interventions. The model demonstrated that smoking cessation interventions, when integrated with TB treatment, had an impact on cessation outcomes in these populations.

Indexed as

Smoking CessationTuberculosisAdultCluster AnalysisFemaleHumansLongitudinal StudiesMaleMiddle AgedRandomized Controlled Trials as Topic

Identifiers

PMID41071782
PMCPMC12513658

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.