Evidence map›Paper›PMID 41071743›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2025

Vaccine and Treatment Evaluation Units: A Historical Perspective.

Robert B Belshe, David I Bernstein, Kathryn M Edwards, Sharon E Frey, Wendy A Keitel, Myron M Levine, John J Treanor, Peter F Wright

Abstract readHistorical Article
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Innovations in Career Development Through Mentoring in the VTEU/IDCRC Programs.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert B BelsheCenter for Vaccine Development, Saint Louis University, Saint Louis, Missouri, USA.ORCID 0000-0003-0940-7213
David I BernsteinCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-0100-1991
Kathryn M EdwardsVanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-3912-9832
Sharon E FreyCenter for Vaccine Development, Saint Louis University, Saint Louis, Missouri, USA.ORCID 0009-0008-6313-4053
Wendy A KeitelMolecular Virology & Microbiology and Medicine, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-0217-332X
Myron M LevineCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
John J TreanorDepartment of Medicine, University of Rochester School of Medicine, Rochester, New York, USA.
Peter F WrightVanderbilt Vaccine Research Program.

Funding

Leadership Group for the Infectious Diseases Clinical Research Consortium (IDCRCLG) - Momi-Vax DMID #21-0004 {Supplement #6}UM1AI148684 · NIAID · EMORY UNIVERSITY · PI DAVID S STEPHENS · 2020 to 2026
$77.2M
NIAID NIH HHS UM1 AI148684
6 · The paper itself

Abstract

On 27 February 1962, Surgeon General Luther Terry announced a new vaccine development program within the National Institute of Allergy and Infectious Diseases (NIAID). Initially, the plan had three components: (1) special laboratories and facilities for development of prototype vaccines; (2) pilot lot production facilities and preliminary vaccine trial sites; and (3) larger lot production capacity and expanded human testing. Respiratory viruses were targeted as the top priority for vaccine development. Over 5 decades, this program has evolved and expanded to include multiple academic vaccine evaluation sites within the network, now labeled as the Vaccine and Treatment Evaluation Units (VTEUs). The network has evaluated many different vaccines, with many shown to be safe, effective, and licensed for recommended use. This manuscript offers a historical perspective, crafted by early investigators from currently funded VTEUs, to showcase how some of the original VTEUs-both individually and collectively-advanced vaccine science and shaped the strategies and achievements that continue to impact public health today.

Indexed as

Vaccine DevelopmentVaccinesHistory, 20th CenturyHistory, 21st CenturyHumansNational Institute of Allergy and Infectious Diseases (U.S.)United StatesVaccines

Identifiers

PMID41071743
PMCPMC12584975

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.