ReviewExperimental physiology2026
The skeletal muscle-adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management.
Review in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- AAV9-mediated GAA gene therapy following enzyme replacement therapy discontinuation in children with infantile-onset Pompe disease.EClinicalMedicine · 2026Article
- The skeletal muscle-adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management.Experimental physiology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise-induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism. Creatine, as the primary carrier of high-energy phosphate bonds within cells, is gaining attention for its role in the metabolic reprogramming of adipose tissue. This review aims to clarify the synergistic regulatory mechanisms between exercise and creatine metabolism, and introduces an innovative 'skeletal muscle-adipose creatine metabolic axis' model. Exercise may upregulate the expression of the creatine transporter in skeletal muscle by activating the AMP-activated protein kinase/peroxisome proliferator-activated receptor γ coactivator 1-α signalling pathway, enhancing phosphocreatine shuttle kinetics, and thereby increasing energy metabolism efficiency. Concurrently, exercise-induced exosomes or miRNAs from skeletal muscle may regulate the futile creatine cycle in adipose tissue and activate non-uncoupling protein 1-dependent thermogenic pathways, thus alleviating obesity conditions. This model not only reveals the multi-organ cross-talk mechanism mediated by exercise in lipid metabolism regulation but also provides a theoretical basis for creatine metabolism-targeted obesity interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.