ArticleExperimental physiology2025
Time-course analysis of cerebral circulation and cardiorespiratory responses to acute central blood volume reduction in healthy young males.
Article in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Defying gravity: Breath, beat and brain.Experimental physiology · 2025Article
- Time-course analysis of cerebral circulation and cardiorespiratory responses to acute central blood volume reduction in healthy young males.Experimental physiology · 2025Article
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Authors and funding
8 authors.
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Abstract
Central blood volume (CBV) reduction challenges circulatory and respiratory homeostasis, particularly during the initial compensatory phase (0-2 min), when rapid physiological adaptations occur. In this study, we examined dynamic cardiorespiratory responses to CBV reduction using lower-body negative pressure (LBNP) in 11 healthy young males. Participants completed three standardized 2 min LBNP trials at -45 mmHg, with respiratory variables assessed via flow measurement and breath-by-breath gas analysis, while cardiovascular parameters and cerebral blood flow were monitored using ECG, blood pressure and transcranial Doppler ultrasonography. During LBNP exposure, thoracic admittance, an indicator of CBV reduction, decreased by 13.4% (p < 0.001), indicating significant CBV reduction. Following rigorous statistical correction for multiple comparisons, time-course analysis revealed that mean blood pressure decreased temporarily during the initial phase (0-30 s), whereas heart rate increased progressively (16.4%, p < 0.001). End-tidal
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