Evidence map›Paper›PMID 41071701›Full record

ArticleIEEE transactions on medical imaging2026

Deep Few-View High-Resolution Photon-Counting CT at Halved Dose for Extremity Imaging.

Mengzhou Li, Chuang Niu, Ge Wang, Maya R Amma, Krishna M Chapagain, Stefan Gabrielson, Andrew Li, Kevin Jonker, Niels de Ruiter, Jennifer A Clark and 3 more

Abstract read
In one paragraph

Article in IEEE transactions on medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Mengzhou Li
Chuang Niu
Ge Wang
Maya R Amma
Krishna M Chapagain
Stefan Gabrielson
Andrew Li
Kevin Jonker
Niels de Ruiter
Jennifer A Clark
Phil Butler
Anthony Butler
Hengyong Yu

Funding

Cardiac CT DebloomingR01HL151561 · NHLBI · GENERAL ELECTRIC GLOBAL RESEARCH CTR · PI BUDOFF, MATTHEW J, DE MAN, BRUNO · 2020 to 2023
$3.8M
Development and Validation of Prognostic Radiomic Markers of Response and Recurrence for Patients with Colorectal Liver MetastasesR01CA233888 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHUN, YUN SHIN, DO, RICHARD KINH GIAN · 2019 to 2023
$3.7M
Photon-counting X-ray and Optical Tomography for Preclinical Cancer ResearchR01CA237267 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI BARROSO, MARGARIDA, INTES, XAVIER · 2019 to 2023
$2.9M
Constrained Disentanglement (CODE) Network for CT Metal Artifact Reduction in Radiation TherapyR01EB031102 · NIBIB · RENSSELAER POLYTECHNIC INSTITUTE · PI DE MAN, BRUNO, PAGANETTI, HARALD · 2021 to 2021
$2.6M
Unsupervised Deep Photon-Counting Computed Tomography Reconstruction for Human Extremity ImagingR01EB034737 · NIBIB · UNIVERSITY OF MASSACHUSETTS LOWELL · PI Hengyong Yu · 2023 to 2026
$2.3M
NCI NIH HHS R01 CA233888NCI NIH HHS R01 CA237267NHLBI NIH HHS R01 HL151561NIBIB NIH HHS R01 EB031102NIBIB NIH HHS R01 EB034737
6 · The paper itself

Abstract

X-ray photon-counting computed tomography (PCCT) for extremity allows multi-energy high-resolution (HR) imaging but its radiation dose can be further improved. Despite the great potential of deep learning techniques, their application in HR volumetric PCCT reconstruction has been challenged by the large memory burden, training data scarcity, and domain gap issues. In this paper, we propose a deep learning-based approach for PCCT image reconstruction at halved dose and doubled speed validated in a New Zealand clinical trial. Specifically, we design a patch-based volumetric refinement network to alleviate the GPU memory limitation, train network with synthetic data, and use model-based iterative refinement to bridge the gap between synthetic and clinical data. Our results in a reader study of 8 patients from the clinical trial demonstrate a great potential to cut the radiation dose to half that of the clinical PCCT standard without compromising image quality and diagnostic value.

Indexed as

Deep LearningExtremitiesImage Processing, Computer-AssistedTomography, X-Ray ComputedHumansPhotonsRadiation Dosage

Identifiers

PMID41071701
PMCPMC13033353

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.