ArticleDevelopment (Cambridge, England)2025
A molecular, spatial and regulatory atlas of the Hydra vulgaris nervous system.
Article in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Control of water excretion in Hydra vulgaris by neural integration.Current biology : CB · 2026Article
- A single-cell transcriptomic atlas reveals the emergence of medusa-specific cell states in the scyphozoan Aurelia coerulea.PLoS biology · 2026Article
- Revisiting nerve nets: functional organization and evolutionary implications.The EMBO journal · 2026Review
- Sustained ERK signaling couples the injury response to organizer formation during Hydra head regeneration.Developmental biology · 2026Article
- Dynamic cell fate transitions during morphallactic regeneration.Nature communications · 2026Article
- International workshop report on "Animal resilience and organismal response to environmental change: insights from basal metazoans", Tutzing (Germany), 22-25 September 2025.Frontiers in zoology · 2026Article
- An updated and spatially validated somatic single-cell atlas of Hydractinia symbiolongicarpus.BMC genomics · 2025Article
- Extracellular matrix remodeling supportsbioRxiv : the preprint server for biology · 2025Article
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13 authors.
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Abstract
Hydra vulgaris, a cnidarian with a simple nerve net, is an emerging model for developmental, regenerative and functional neuroscience. Its genetic tractability and capacity for whole-system imaging make it well suited for studying neuron replacement, regeneration and neural circuit function. Here, we present the most comprehensive molecular and spatial characterization of the H. vulgaris nervous system to date. Using single-cell RNA sequencing, we identified eight neuron types, each defined by distinct neuropeptide expression, and further resolved these into 15 transcriptionally distinct subtypes with unique spatial distributions and morphologies. These data enabled a detailed examination of the molecular components of neuronal communication and excitability. To investigate the gene regulatory networks underlying neuronal differentiation, we applied trajectory inference, identified key transcription factors, and performed ATAC-seq on sorted neurons to map chromatin accessibility. All datasets are available through an interactive, user-friendly web portal to support broad use by the research community. Together, these resources provide a foundation for uncovering molecular mechanisms that govern nervous system development, homeostasis, regeneration and function in H. vulgaris.
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