Evidence map›Paper›PMID 41071655›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Unexpected heterogeneity and tissue-specific properties of the thymic hematopoietic antigen-presenting cell network.

Yi Wang, Xin Liu, Amelie C Bond, Seungyoul Oh, Sotaro Ochiai, Abbie R Larson, Anita E Qualls, Im Hong Sun, Michaël Chopin, James M Gardner and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Thymic Dendritic Cells Revisited.Immunological reviews · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yi WangSt. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.ORCID 0000-0002-1263-1470
Xin LiuSt. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.ORCID 0000-0002-7869-4730
Amelie C BondSt. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.
Seungyoul OhSt. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.
Sotaro OchiaiMalaghan Institute of Medical Research, Wellington 6012, New Zealand.ORCID 0000-0003-1669-8899
Abbie R LarsonMalaghan Institute of Medical Research, Wellington 6012, New Zealand.ORCID 0009-0000-5987-1191
Anita E QuallsDepartment of Surgery, University of California San Francisco, San Francisco, CA 94143.
Im Hong SunDepartment of Surgery, University of California San Francisco, San Francisco, CA 94143.
Michaël ChopinWalter and Eliza Hall Institute of Medical Research, Parkville, VIC 3010, Australia.
James M GardnerDepartment of Surgery, University of California San Francisco, San Francisco, CA 94143.
Stephen L NuttWalter and Eliza Hall Institute of Medical Research, Parkville, VIC 3010, Australia.ORCID 0000-0002-0020-6637
Franca RoncheseMalaghan Institute of Medical Research, Wellington 6012, New Zealand.ORCID 0000-0001-5835-8230
Daniel G PellicciDepartment of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia.
Mark M W ChongSt. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.ORCID 0000-0002-3701-7397

Funding

Diabetes Australia Y20G-CHOMFederal Government | DHAC | National Health and Medical Research Council (NHMRC) 1079586 1117154 1122384 and 1122395U.S. Department of Defense (DOD) W81XWH-19-1-0728
6 · The paper itself

Abstract

Thymic hematopoietic antigen-presenting cells (hAPCs) play critical roles in regulating T cell development, but the identity, diversity, and transcriptional regulation of these cells are poorly understood. To address this, we characterized mouse thymic hAPCs in an unbiased manner utilizing physical interactions. Transcriptional profiling revealed the presence of CD8α

Indexed as

Antigen-Presenting CellsThymus GlandAnimalsCell DifferentiationDendritic CellsHumansMiceMice, Inbred C57BLOrgan SpecificityReceptors, ImmunologicReceptors, Immunologicantigen–presenting cellsdendritic cellsmacrophagesthymustissue-specific antigens

Identifiers

PMID41071655
PMCPMC12541397

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.