Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Moien LoneDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, United States.
Parvind SinghDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, United States.
James Sinnett-SmithVatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, United States.ORCID 0000-0003-0074-7270
Yi-Ping JinDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, United States.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, United States.ORCID 0000-0002-3524-545X
Enrique RozengurtVatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, United States.ORCID 0000-0002-7838-9170
Funding
Regulation of Innate Immune Responses by Alloimmunity in Liver Ischemia-Reperfusion InjuryP01AI120944 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELAINE F REED · 2017 to 2026
$20.0M
Systems Epigenomics of Persistent Bloodstream InfectionU19AI172713 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Michael R Yeaman · 2023 to 2026
$11.6M
Project 3: Role of the pancreatic fibroinflammatory microenvironment in obesity-promoted pancreatic cancerP01CA236585 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EIBL, GUIDO ERWIN MICHAEL · 2020 to 2024
$5.6M
The role of HLA and its coreceptors in endothelial cell activation and leukocyte recruitment in antibody-mediated transplant rejectionR01AI135201 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert L Fairchild, ELAINE F REED · 2018 to 2026
$5.3M
Targeting the transcriptional co-activators YAP and TAZ with statins to prevent solid organ transplant rejection by HLA donor specific antibodiesR01AI173050 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert L Fairchild, ELAINE F REED · 2023 to 2026
$2.9M
Systems analyses of induction and maintenance of immunity to SARS-CoV-2 vaccination in kidney transplant recipients receiving mycophenolate mofetil immunotherapyU01AI179524 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELAINE F REED · 2024 to 2026
$1.9M
HHS | NIH | National Cancer Institute (NCI) P01CA236585HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) P01AI120944HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI135201HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI173050HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U01AI179524HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI172713NCI NIH HHS P01 CA236585NIAID NIH HHS P01 AI120944NIAID NIH HHS R01 AI135201NIAID NIH HHS R01 AI173050NIAID NIH HHS U01 AI179524NIAID NIH HHS U19 AI172713
6 · The paper itself
Abstract
Piezo1 is an evolutionally conserved mechanosensitive ion channel implicated in the regulation of development, differentiation, and growth of multiple tissues. Despite its importance, the pathways induced downstream of Piezo1 activation remain incompletely defined. Here, we report that the selective Piezo1 agonists, Yoda1, Yaddle1, and Yoda2, stimulate Protein kinase D (PKD) family activation in a concentration-dependent manner, in human aortic endothelial cells (ECs), as shown by an increase in PKD phosphorylation at Ser
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Activation of the Piezo1 channel stimulates protein kinase D and migration in human aortic endothelial cells. · full record | OpenQuestion