SynthesisJornal brasileiro de nefrologia
Frequency of acute kidney injury in post-liver transplantation and associated factors: a systematic review.
Synthesis in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Assessment of the Factors That Predict Post-Transplant Mortality in Autoimmune Liver Disease Recipients.Medicina (Kaunas, Lithuania) · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute kidney injury (AKI) is a common complication following liver transplantation (LT). It is associated with factors such as perioperative hemodynamic instability, prolonged surgery, and use of nephrotoxic immunosuppressants, contributing to increased mortality, graft failure, and extended hospital stay.
methodsA systematic search of the databases PubMed, Embase, and the Cochrane Central Register of Controlled Trials was conducted to identify observational studies with samples of at least 50 patients aged 18 years or older who underwent LT and analyzed AKI incidence post-procedure and assess long-term renal outcomes.
resultsA total of 30 studies with a total of 13,653 patients were included. The incidence of AKI post-LT was 46% (95% CI: 45%-47%), with significant variation across studies (24% to 84%) and high heterogeneity (I2 = 97%, p < 0.001). The pooled incidence of dialysis requirement post-LT was 10% (95% CI: 9%-11%), also highly variable across studies (2% to 36%) with high heterogeneity (I2 = 95%, p < 0.001). Common postoperative complications included prolonged mechanical ventilation, graft dysfunction, infections, and hypertension (HTN). Furthermore, the analysis highlighted significant AKI risk factors, such as HTN, diabetes, hyperlactatemia, hyperbilirubinemia, and prolonged hospitalization.
conclusionAKI and dialysis requirements are frequent complications following LT. Multiple risk factors, including HTN, diabetes, and prolonged hospitalization, are associated with an increased risk of AKI post-LT. The high incidence of AKI underscores the importance of early identification of at-risk patients and multidisciplinary approaches to improve outcomes.
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