SynthesisOdontology2026
Impact of IL-17A rs2275913 allelic variation on periodontitis susceptibility: evidence from a meta-analysis.
Synthesis in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-17A (IL-17A) plays a vital immunomodulatory role in periodontal disease. While the IL-17A rs2275913 polymorphism has been investigated for its potential influence on periodontitis risk, reported associations remain inconsistent. To conduct a systematic review and meta-analysis evaluating the relationship between the IL-17A rs2275913 polymorphism and susceptibility to periodontitis. Case-control studies were systematically retrieved from PubMed, Embase, and Web of Science (inception to July 2025). Strict criteria were enforced during data extraction and quality assessment using the Newcastle-Ottawa Scale(NOS). Meta-analysis was performed using STATA to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs), assessing heterogeneity, performing subgroup analyses, evaluating sensitivity, and detecting publication bias. 11 studies (1409 periodontitis cases, 1367 controls) were included. A significant association between the rs2275913 polymorphism and periodontitis risk was identified under the following genetic models: Allele model (G vs A): OR = 0.87, 95% CI 0.77-0.98; Homozygous model (GG vs AA): OR = 0.70, 95% CI 0.55-0.90; Dominant model (GG+GA vs AA): OR = 0.78, 95% CI 0.62-0.98. Subgroup analyses indicated significant associations within Asian populations but not European populations, and in studies employing healthy controls but not those using type 1 diabetes (T1DM) patients or other control groups. Publication bias was not statistically significant. Findings remained consistent upon sensitivity analysis, confirming robustness. The IL-17A rs2275913 polymorphism is significantly associated with periodontitis susceptibility. The G allele and GG genotype appear to confer a protective effect. This association is particularly evident in Asian populations and studies utilizing healthy controls.
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Registered trials
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