Trial reportPituitary2025
Effect of oral urea ingestion on growth hormone levels in healthy adults - a secondary analysis of a randomized, double-blind, placebo-controlled cross-over trial.
Trial report in Pituitary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAvailable stimulation tests for growth hormone (GH) deficiency are burdensome or require intravenous access, highlighting the need for accessible, oral options. Increasing plasma urea through oral ingestion may stimulate GH secretion via feedback regulation. In this analysis, we investigated the effect of oral urea on GH levels.
methodsThis is a secondary analysis of a double-blind, randomized, placebo-controlled cross-over trial in healthy adults. They received a single weight-adapted dose of oral urea (0.5 g/kg body weight; 30-45 g) or placebo in random order. Serum GH was measured at baseline, 60 and 120 min. The main outcome was the difference in absolute GH levels after placebo and urea intake.
resultsOf 22 healthy adults, 12 (55%) were female, with a median [IQR] age of 27 years [26, 32] and a body mass index of 23.3 kg/m
conclusionOral urea does not significantly stimulate GH secretion and cannot be used as a stimulation test for GH deficiency.
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