Evidence map›Paper›PMID 41071373›Full record

ArticleHistochemistry and cell biology2025

Silica nanoparticles trigger striatal oxidative stress, apoptosis, and histopathological alterations: in vivo and in silico molecular docking insights.

Khadija Boukholda, Bakhta Aouey, Yassine Chtourou, Eman Elbayoumi, Melania Guerrero-Hue, Cristina García-Caballero, Fatma Boukholda, Mercedes Vallejo-Mudarra, Bilqees Sameem, Fatiha Chigr and 3 more

Abstract read
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In one paragraph

Article in Histochemistry and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. December In focus in HCB.Histochemistry and cell biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Khadija BoukholdaLaboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia. khadijaboukholdafss@gmail.com.
Bakhta AoueyLaboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.
Yassine ChtourouLaboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.
Eman ElbayoumiDepartment of Neurobiology, Center for Neurotrauma, Multiomics and Biomarkers (CNMB), Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA.
Melania Guerrero-HueDepartment of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain.
Cristina García-CaballeroDepartment of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain.
Fatma BoukholdaLaboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.
Mercedes Vallejo-MudarraDepartment of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain.
Bilqees SameemBioengineering Laboratory, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, 23000, Beni Mellal, Morocco.
Fatiha ChigrComplex Carbohydrate Research Center, University of Georgia, Athens, USA.
Michèle BouchardDepartment of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, U436, Main Station, P.O. Box 6128, Montreal, QC, H3C 3J7, Canada.
Juan Antonio MorenoDepartment of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain.
Hamadi FetouiLaboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans are increasingly exposed to silica nanoparticles (SiNPs) from environmental and occupational sources, raising significant concerns about their safety. Despite growing applications, data on their neurotoxic effects, particularly those involving oxidative/nitrosative imbalance and striatal damage, remain limited. This study aimed to elucidate the mechanisms of SiNP-induced neurotoxicity in the striatum, a brain region crucial for motor control and learning, using a rat model. Subacute intraperitoneal administration of SiNPs (25 and 100 mg/kg bw/day for 28 days) resulted in a marked increase in lipid peroxidation (LPO), reactive oxygen species (ROS), nitrite (NO), and protein carbonyl content, alongside a significant reduction in the activity of antioxidant enzymes, viz. superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as glutathione (GSH). Additionally, cholinergic [acetylcholinesterase (AChE) and b1utyrylcholinesterase (BChE)] and membrane-bound adenosine triphosphate (ATP)ase (Na

Indexed as

ApoptosisCorpus StriatumMolecular Docking SimulationNanoparticlesOxidative StressSilicon DioxideAnimalsMaleRatsRats, WistarSilicon DioxideAChEApoptotic pathwayNrf-2/HO-1Oxidative stressSiNPsStriatum

Identifiers

PMID41071373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.