Evidence map›Paper›PMID 41071370›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

The trajectory of cancer-related fatigue throughout lung cancer treatment and its association with physical activity.

Francesca Van Hulle, Eva Arents, Kirsten Quadflieg, Sarah Haesevoets, Fien Hermans, Maarten Criel, David Ruttens, Eric Derom, Marc Daenen, Martijn A Spruit and 4 more

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Francesca Van HulleDepartment of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
Eva ArentsDepartment of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
Kirsten QuadfliegCentre of Expertise in Care Innovation, Department of PXL - Healthcare, PXL University of Applied Sciences and Arts, Hasselt, Belgium.
Sarah HaesevoetsREVAL - Rehabilitation Research Center, BIOMED - Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium.
Fien HermansDepartment of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
Maarten CrielDepartment Lung Diseases, Ziekenhuis Oost-Limburg, Genk, Belgium.
David RuttensDepartment Lung Diseases, Ziekenhuis Oost-Limburg - Faculty of Medicine and Life Sciences, Hasselt University, Genk, Belgium.
Eric DeromDepartment of Pulmonary Medicine, Ghent University Hospital, Ghent, Belgium.
Marc DaenenDepartment Lung Diseases, Ziekenhuis Oost-Limburg, Genk, Belgium.
Martijn A SpruitCIRO, Center of Expertise for Chronic Organ Failure, Department of Research and Education - Department of Respiratory Medicine, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University Medical Centre, Horn, Maastricht, The Netherlands.
Veerle SurmontDepartment of Pulmonary Medicine, Ghent University Hospital, Ghent, Belgium.
Dieter StevensDepartment of Pulmonary Medicine, Ghent University Hospital, Ghent, Belgium.
Chris Burtin *REVAL - Rehabilitation Research Center, BIOMED - Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium.
Heleen Demeyer *Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium. h.demeyer@ugent.be.

Funding

Bijzonder Onderzoeksfonds UGent BOF21KP15Bijzonder Onderzoeksfonds UGent BOF.STG.2021.0013.01Fonds Wetenschappelijk Onderzoek 12H7517NFonds Wetenschappelijk Onderzoek G0A0125N
6 · The paper itself

Abstract

backgroundCancer-related fatigue (CRF) is a debilitating symptom in patients with lung cancer and is often more severe than in other cancer populations. This study investigated the impact of different cancer treatments on CRF trajectories and the role of physical activity (PA) during treatment.

methodsPatients with non-small cell lung cancer (NSCLC) were included. CRF was assessed at diagnosis, during treatment, and 12 weeks after treatment initiation using the Multidimensional Fatigue Inventory (MFI-20). ΔMFI-20 (T

resultsSixty-two patients (66 ± 8 years, 66% male) were included. CRF increased significantly more in patients receiving surgery and (neo-)adjuvant treatment (n = 12) compared to surgery alone (n = 29) (ΔMFI-20, 16 ± 17 vs. 0.3 ± 13; p < 0.05). The increase in CRF in non-surgically treated patients (n = 21) (ΔMFI-20, 6 ± 19) was not statistically different (p = 0.41) from those receiving surgery. Patients performed 3695 ± 2288 steps/day and 11 ± 14 min of MVPA/day during treatment. Patients engaging in higher levels of PA during treatment (> 5000 steps/day or > 10 min of MVPA/day) tended to have lower CRF increases compared to most inactive patients (< 3000 steps/day) (ΔMFI-20, 6.4 ± 4.9; p = 0.06).

conclusionsPatients with lung cancer experience significant increases in CRF throughout treatment, particularly those receiving (neo-)adjuvant treatment and surgery. PA levels during treatment were very low and tended to be related to lower fatigue increases. These findings highlight the importance of measuring CRF and the potential for exploring PA interventions to manage CRF.

Indexed as

Carcinoma, Non-Small-Cell LungExerciseFatigueLung NeoplasmsAgedFemaleHumansMaleMiddle AgedAccelerometryCancer-related fatigueLung cancerPhysical activityTreatment

Identifiers

PMID41071370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.