Evidence map›Paper›PMID 41071315›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Fucoidan induces ferroptosis in colorectal cancer cells by regulating the SLC7A11/GPX4 signaling pathway and modulating metabolic pathways.

Chengyu Yang, Chunqi Feng, Naiqi Zhang, Jia Feng, Shulian Xie, Xinghua Li, Qi Liu

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chengyu YangChangzhi People's Hospital, Institute of Upper Gastrointestinal Tumour Prevention and Treatment, Shanxi Medical University, Changzhi, China.
Chunqi FengSchool of Pharmacy, Shanxi Medical University, Taiyuan, China.
Naiqi ZhangChangzhi Medical College, Taiyuan, China.
Jia FengCollege of Life Sciences, Shanxi University, Taiyuan, China.
Shulian XieCollege of Life Sciences, Shanxi University, Taiyuan, China.
Xinghua LiChangzhi People's Hospital, Institute of Upper Gastrointestinal Tumour Prevention and Treatment, Shanxi Medical University, Changzhi, China. xinghualiabc@163.com.
Qi LiuCollege of Life Sciences, Shanxi University, Taiyuan, China. liuqi@sxu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigates the impact of fucoidan on ferroptosis in colorectal cancer (CRC) cells and analyzes its mechanism of action through the SLC7A11/GPX4 signaling pathway.

methodsThe HT-29 colorectal cancer cell line was tested using the CCK-8 cytotoxicity assay to assess how different fucoidan concentrations affect cell survival, and the IC

resultsThe results of the CCK-8 assay, colony formation assay, scratch assay and Transwell assay indicated that fucoidan significantly inhibited the proliferation and migration of HT-29 cells (P < 0.01). The results of Fe

conclusionFucoidan induces ferroptosis in colorectal cancer cells, potentially through the regulation of the SLC7A11/GPX4 signaling pathway and associated metabolic pathways, including amino acid and lipid metabolism.

Indexed as

Amino Acid Transport System y+Antineoplastic AgentsColorectal NeoplasmsFerroptosisGlutathione PeroxidasePolysaccharidesCell MovementCell ProliferationCell SurvivalGlutathioneHT29 CellsHumansMetabolic Networks and PathwaysPhospholipid Hydroperoxide Glutathione PeroxidaseSignal TransductionAmino Acid Transport System y+Antineoplastic AgentsfucoidanGlutathioneGlutathione PeroxidasePhospholipid Hydroperoxide Glutathione PeroxidasePolysaccharidesSLC7A11 protein, humanCell metabolomicsColorectal cancerFucoidanIron death

Identifiers

PMID41071315

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.