Evidence map›Paper›PMID 41071239›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Insomnia associated with patient-reported outcomes in head and neck cancer survivors.

Purva H Rumde, Daniel R Awad, Jinhong Li, Kevin J Contrera, Harish Dharmarajan, Alexandria Harris, Christine Harrison, Ryan J Soose, Jonas Johnson, Marci L Nilsen

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Purva H Rumde *School of Medicine, University of Pittsburgh, School, Pittsburgh, PA, USA.
Daniel R Awad *Division of Internal Medicine, Grossman School of Medicine, New York University, New York, NY, USA.
Jinhong LiDepartment of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Kevin J ContreraDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, University of Pittsburgh, PA, Pittsburgh, USA.
Harish DharmarajanSanta Clara Valley Medical Center, San Jose, CA, USA.
Alexandria HarrisDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, University of Pittsburgh, PA, Pittsburgh, USA.
Christine HarrisonDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, University of Pittsburgh, PA, Pittsburgh, USA.
Ryan J SooseDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, University of Pittsburgh, PA, Pittsburgh, USA.
Jonas JohnsonDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, University of Pittsburgh, PA, Pittsburgh, USA.
Marci L NilsenDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, University of Pittsburgh, PA, Pittsburgh, USA. mlf981@pitt.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the prevalence and risk factors of insomnia and to explore associations between insomnia and patient-reported outcomes in head and neck cancer (HNC) survivors.

methodsCross-sectional analysis was performed on questionnaires completed by survivors with primary squamous cell carcinoma of the oral cavity, oropharynx, or laryngopharynx seen in a multidisciplinary HNC survivorship clinic from August 2018 to August 2022 at a single academic medical center. Insomnia, quality of life (QOL), and symptoms of dysphagia severity, anxiety, and depression were assessed using the Insomnia Severity Index, University of Washington QOL, Eating Assessment Tool-10, Generalized Anxiety Disorder 7-item, and Patient Health Questionnaire-8. Multivariable regression analysis and trend tests were used to evaluate these relationships.

resultsA total of 827 HNC survivors, median 9 months post-treatment, were included. Tumors were most commonly oropharyngeal (51.0%), T stage 1-2 (57.3%), and treated by surgery with adjuvant radiation/chemoradiation (45.5%). Of the survivors, 21.4% of patients reported subthreshold insomnia, and 13.1% had clinical insomnia. Insomnia was associated with worse physical and social-emotional QOL scores and greater symptoms of anxiety, depression, dysphagia, and neck disability (all p < 0.001).

conclusionsThe prevalence of insomnia among HNC survivors is 34.5%. Insomnia was associated with decreased QOL and higher symptom burden, including anxiety, depression, dysphagia, and neck disability. IMPLICATIONS FOR SUPPORTIVE CARE IN SURVIVORS OF HNC: Screening for insomnia should be considered in HNC survivorship care to identify individuals who may benefit from comprehensive interventions that include sleep-focused strategies, which could also improve patient-reported outcomes.

Indexed as

Cancer SurvivorsHead and Neck NeoplasmsPatient Reported Outcome MeasuresSleep Initiation and Maintenance DisordersAdultAgedAnxietyCross-Sectional StudiesDeglutition DisordersDepressionFemaleHumansMaleMiddle AgedPrevalenceQuality of LifeDisabilityHead and neck cancerInsomniaMental healthQuality of lifeSurvivorship

Identifiers

PMID41071239

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.