ArticleEuropean geriatric medicine2025
Basal metabolic rate predicts dementia in community-dwelling older adults: a 5-year longitudinal study.
Article in European geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Associations of Dietary Antioxidant and Phytochemical Indices with Cognitive Function: Mediating Roles of Basal Metabolic Rate and Systemic Inflammation.Antioxidants (Basel, Switzerland) · 2026Article
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6 authors.
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Abstract
purposeAlthough basal metabolic rate (BMR) is reportedly associated with physiological function decline, there is no consensus regarding its relationship with cognitive function. Therefore, we investigated the relationship between BMR and dementia risk over a 5-year period in 2550 of the 2975 older adults who were available for analysis (age 73.2 ± 6.0 years, 59.8% women).
methodsBMR was calculated using the TANITA, Mifflin-St Jeor, Harris-Benedict, and Cunningham equations. Furthermore, the BMR assessment method developed by the National Institute of Health and Nutrition (NIBIOHN) was used. Participants were classified into quartiles for BMR obtained using each method. Cox proportional hazards regression analysis was performed using the highest quartile (Q4) of each BMR to evaluate the association between BMR and dementia risk. Additionally, differences in the performance of each formula in predicting dementia risk were examined using the time-dependent receiver operating characteristic curve.
resultsParticipants in the lowest BMR quartile (Q1) had a higher risk of dementia than those in Q4 [TANITA BMR: hazard ratio (HR) = 2.49, p < 0.001; Harris-Benedict BMR: HR = 1.70, p < 0.05; Mifflin-St. Jeor BMR: HR: 3.83, p < 0.001; Cunningham BMR: HR = 2.78, p < 0.001; NIBIOHN BMR: HR = 2.98, p < 0.001]. The time-dependent ROC of Harris-Benedict BMR demonstrated the highest predictive accuracy among all BMRs calculated (area under the curve = 0.71, p < 0.05).
conclusionOur results reveal the association of low BMR with increased dementia risk, suggesting its potential as an early predictive biomarker, and demonstrate the usefulness of the Harris-Benedict equation for predicting dementia risk.
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