Evidence map›Paper›PMID 41071169›Full record

ArticleThe Veterinary record2025

Randomised controlled field trial to assess the safety and efficacy of a killed autologous vaccine against Streptococcus dysgalactiae subspecies dysgalactiae in a sheep flock.

Joseph W Angell, Naseem Ahmed, Louise P Jackson, Konstantina Kasiora, Keith Ballingall, Jennifer S Duncan

Abstract readRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in The Veterinary record, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joseph W AngellDepartment of Research and Innovation, Wern Vets, Ruthin, UK.ORCID https://orcid.org/0000-0002-3684-0277
Naseem AhmedDepartment of Livestock and One Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, UK.
Louise P JacksonDepartment of Livestock and One Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, UK.
Konstantina KasioraDepartment of Livestock and One Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, UK.
Keith BallingallMoredun Research Institute, Penicuik, UK.
Jennifer S DuncanDepartment of Livestock and One Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, UK.ORCID https://orcid.org/0000-0002-1370-3085

Funding

AHDBArwain DGCUniversity of Liverpool MRes programme
6 · The paper itself

Abstract

introductionJoint-ill in neonatal lambs, primarily caused by Streptococcus dysgalactiae subspecies dysgalactiae (SDSD), results in increased mortality and morbidity. An effective vaccine is needed to prevent the disease.

methodsA blinded randomised controlled trial was carried out using an autologous SDSD vaccine in a commercial sheep flock in the UK. Two doses of vaccine were administered to 481 pregnant ewes, with 509 ewes left unvaccinated. The SDSD antibody titres of the ewes and their lambs were then measured. Any adverse effects or cases of joint-ill were also reported.

resultsTen cases of joint-ill occurred, with five of these lambs born to vaccinated ewes and five to unvaccinated ewes. Serum from 85 vaccinated ewes and 88 control ewes was analysed using an SDSD antibody ELISA, with higher titres found in vaccinated ewes. Higher SDSD titres were observed in lambs from vaccinated ewes (n = 87) than in lambs from unvaccinated ewes (n = 91). No differences were detected between colostrum samples from vaccinated and unvaccinated ewes. No vaccination-associated adverse effects were detected. LIMITATIONS: Randomisation was effective; however, ELISA data were limited to mainly crossbred ewes, reducing the power of the breed comparisons.

conclusionsThe vaccine had no effect in reducing the number of lambs with joint-ill born to vaccinated ewes compared with unvaccinated ewes. However, vaccinating ewes did have a positive effect on their serum SDSD antibody concentrations and those of their lambs.

Indexed as

Sheep DiseasesStreptococcal InfectionsStreptococcal VaccinesStreptococcusAnimalsAnimals, NewbornAutovaccinesFemalePregnancySheepTreatment OutcomeUnited KingdomVaccinationVaccines, InactivatedAutovaccinesStreptococcal VaccinesVaccines, Inactivatedefficacyjoint‐illlambsneonatal infectious arthritisStreptococcus dysgalactiae subspecies dysgalactiaevaccine

Identifiers

PMID41071169
PMCPMC12617486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.