Evidence map›Paper›PMID 41070989›Full record

ArticleMicrobiology spectrum2025

Emergence and dissemination of

Betsy E Castro, Elsa De la Cadena, Janneth J Escobar-Arcos, Juan C García-Betancur, Natalia Restrepo-Arbeláez, Christian Pallares, María J López, Angela Pescador, Juan Escobar T, Lorena Matta-Cortes and 2 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Betsy E CastroGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá D.C., Colombia.ORCID 0000-0003-1179-5382
Elsa De la CadenaGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá D.C., Colombia.ORCID 0000-0003-0361-7893
Janneth J Escobar-ArcosGestión Pre-Transfusional Laboratorio y Patología, Clínica Imbanaco Grupo Quirónsalud, Cali, Colombia.
Juan C García-BetancurGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá D.C., Colombia.ORCID 0000-0001-5569-6031
Natalia Restrepo-ArbeláezGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá D.C., Colombia.ORCID 0009-0005-9784-6700
Christian PallaresGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá D.C., Colombia.
María J LópezServicio de infectología, Centro de Tratamiento e Investigación sobre el Cáncer Luis Carlos Sarmiento Angulo (CTIC), Bogotá, Colombia.ORCID 0000-0001-9865-9097
Angela PescadorGrupo de Investigación en Medicina Cardiovascular y Especialidades de Alta Complejidad, Fundación Clínica SHAIO, Bogotá, Colombia.
Juan Escobar THospital Federico Lleras Acosta, Ibagué, Colombia.
Lorena Matta-CortesUniversidad del Valle, Cali, Colombia.
Adriana C Palacios-LarrotaDepartamento de patología y medicina del laboratorio, Fundación Valle del Lili, Cali, Colombia.
María Virginia VillegasGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá D.C., Colombia.ORCID 0000-0003-1898-9067

Funding

bioMérieux 1862 and E0878Pfizer Foundation MAPP-034284
6 · The paper itself

Abstract

Ceftazidime/avibactam (CZA) is a promising treatment option for infections caused by carbapenem-resistant Enterobacterales (CRE). However, CZA resistance is increasingly reported worldwide, largely due to the emergence of KPC variants and increase of metallo-β-lactamases (MBL). This study describes the mechanisms associated with CZA resistance in circulating Enterobacterales isolates from Colombia, highlighting the challenge this represents for microbiological identification. Between 2021 and 2024, 68 CZA-resistant Enterobacterales isolates were identified by automated methods in seven Colombian cities. Resistance to CZA was subsequently confirmed by broth microdilution and E-test. Carbapenemase production was evaluated using phenotypic tests, such as the mCIM test, Carba NP, lateral flow assay, and qPCR (

Indexed as

Bacterial Proteinsbeta-LactamasesEnterobacteriaceaeEnterobacteriaceae InfectionsAnti-Bacterial AgentsAzabicyclo CompoundsCeftazidimeColombiaDrug CombinationsDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsWhole Genome SequencingAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-LactamasescarbapenemaseCeftazidimeDrug CombinationsblaKPC-31blaKPC-8blaPAC-2ceftazidime/avibactamColombiaKPC-variants

Identifiers

PMID41070989
PMCPMC12584661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.