Evidence map›Paper›PMID 41070978›Full record

ArticleESC heart failure2025

A heart failure network model to improve outcome and trans-sectoral guideline-directed medical treatment utilization.

Christina Paitazoglou, Dominik Jurczyk, Matthias Mezger, Felicitas Lemmer, Bernhard Schwaab, Patricia Grube, Thomas Helms, Bettina Zippel-Schultz, Buntaro Fujita, Roland Tilz and 4 more

Abstract readMulticenter Study
In one paragraph

Article in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christina PaitazoglouUniversity Heart Center Lübeck, Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Hospital Schleswig-Holstein (UKSH) - Campus Lübeck, Lübeck, Germany.
Dominik JurczykUniversity Heart Center Lübeck, Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Hospital Schleswig-Holstein (UKSH) - Campus Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0002-7440-4986
Matthias MezgerUniversity Heart Center Lübeck, Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Hospital Schleswig-Holstein (UKSH) - Campus Lübeck, Lübeck, Germany.
Felicitas LemmerUniversity Heart Center Lübeck, Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Hospital Schleswig-Holstein (UKSH) - Campus Lübeck, Lübeck, Germany.
Bernhard SchwaabCurschmann Klinik, Timmendorfer Strand, Germany.
Patricia GrubeCurschmann Klinik, Timmendorfer Strand, Germany.
Thomas HelmsGerman Foundation for the Chronically Ill, Berlin, Germany.
Bettina Zippel-SchultzGerman Foundation for the Chronically Ill, Berlin, Germany.
Buntaro FujitaGerman Center for Cardiovascular Research (DZHK), Partner Site Hamburg-Kiel-Lübeck, Lübeck, Germany.
Roland TilzGerman Center for Cardiovascular Research (DZHK), Partner Site Hamburg-Kiel-Lübeck, Lübeck, Germany.
Thomas StiermaierUniversity Heart Center Lübeck, Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Hospital Schleswig-Holstein (UKSH) - Campus Lübeck, Lübeck, Germany.
Christian FrerkerUniversity Heart Center Lübeck, Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Hospital Schleswig-Holstein (UKSH) - Campus Lübeck, Lübeck, Germany.
Stephan EnsmingerGerman Center for Cardiovascular Research (DZHK), Partner Site Hamburg-Kiel-Lübeck, Lübeck, Germany.
Ingo EitelUniversity Heart Center Lübeck, Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Hospital Schleswig-Holstein (UKSH) - Campus Lübeck, Lübeck, Germany.

Funding

Ministry of Justice and Health, Schleswig-Holstein, Germany
6 · The paper itself

Abstract

aimsHeart failure (HF) is a major cause of hospitalization, mortality and healthcare costs. Reducing its socioeconomic burden is a key global public health priority. HF networks are recommended to improve screening and management of HF patients. We developed and implemented a multi-sectoral HF network in Northern Germany aimed at optimizing patient outcomes. METHODS AND

resultsA regional HF network was established by integrating 12 pre-existing local networks into a state-wide, multi-sectoral HF network. Data from HF-coded patients were analysed for two time periods: pre-implementation (2018-2020) and post-implementation (2021-2023). Patient trajectories through the healthcare system were examined using both inpatient and outpatient datasets. We report on the network's implementation across urban, island and rural areas, along with associated challenges and benefits. A roadmap of HF patient trajectories was created, identifying key healthcare entry points and informing a three-pillar theory of change to address the national HF burden. Post-implementation, outpatient treatment cases increased markedly (2018-2020 n = 1237 vs. 2021-2023 n = 2563; +101.3%, P < 0.001), as did referrals from specialists (2018-2020 n = 290 vs. 2021-2023 n = 434, +49.7%, P = 0.013), general practitioners (2018-2020 n = 369 vs. 2021-2023 n = 435, +17.9%, P = 0.26), and inpatient admissions (2018-2020 n = 2342 vs. 2021-2023 n = 2608, +20.7%, P = 0.03). HF rehospitalization rates showed no significant difference yet despite a positive trend (2018-2020 20.3% vs. 2021-2023 17.9%; P = 0.295), while in-hospital mortality remained stable (2018-2020 8.8% vs. 2021-2023 10.2%; P = 0.1).

conclusionsImplementation of a novel multi-sectoral HF network enabled the analysis of patient trajectories and identification of areas for improvement in HF care. Observed shifts in referral patterns and increased treatment activity indicate early positive trends that support the potential of such networks in enhancing HF management and reducing disease burden.

Indexed as

Heart FailurePractice Guidelines as TopicAgedFemaleGermanyHospitalizationHumansMaleMiddle AgedChronic heart failureEpidemiologyGuideline‐directed medical therapyHealth service researchHeart failure network

Identifiers

PMID41070978
PMCPMC12719809

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.