Evidence map›Paper›PMID 41070964›Full record

ReviewCritical reviews in microbiology2026

Current and emerging therapies for fungal biofilms and systemic infections.

Yehia Elgammal, Rafael I Garcia Martinez, Adrian Requejo, Luis R Martinez

Abstract readReview
In one paragraph

Review in Critical reviews in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yehia ElgammalDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA.
Rafael I Garcia MartinezDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA.
Adrian RequejoDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA.
Luis R MartinezDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA.ORCID 0000-0001-6372-6501

Funding

Mechanisms underlying Cryptococcus neoformans-induced meningoencephalitis and neurotoxicity in a CD4 T cell-deficient mouseR01AI187391 · NIAID · UNIVERSITY OF FLORIDA · PI Luis R Martinez · 2025 to 2026
$1.0M
SF2UF: The Bridges to the Baccalaureate partnership between Santa Fe College and the University of FloridaT34GM137869 · NIGMS · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, JULIAN, DAVID · 2021 to 2025
$957k
NIAID NIH HHS R01 AI187391NIGMS NIH HHS T34 GM137869
6 · The paper itself

Abstract

Fungal pathogens pose a global public health risk, driven by the alarming rise of antifungal resistance. The current antifungal pipeline remains limited to three main classes (azoles, polyene, and echinocandins). Additionally, fungal biofilms, with its extracellular matrix, further complicates the antifungal therapeutics. Despite the persistent challenges posed by biofilms in clinical medicine, advancements in research have led to the development of numerous antifungal approaches aimed at inhibiting the fungal growth, disrupting biofilm integrity and overcoming resistance mechanisms. This review explores the current understanding of antifungal resistance in human fungal pathogens, and emphasizes emerging therapeutics, including novel treatments, repurposed drugs, and natural products, with potential to outperform conventional therapies. Future experimental studies will further refine these recent therapeutic approaches, paving the way for innovative and more efficient biofilm eradication approaches.

Indexed as

Antifungal AgentsBiofilmsFungiMycosesAnimalsDrug Resistance, FungalHumansAntifungal AgentsAntifungal drugsbiofilmsextracellular matrixfungitherapeutics

Identifiers

PMID41070964
PMCPMC13433004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.