Evidence map›Paper›PMID 41070844›Full record

ArticleGigaScience2025

Comparative genomics and multiomics analyses reveal the evolution and physiological basis of rubber biosynthesis in Hevea species.

Nyok-Sean Lau, Emiko Okubo-Kurihara, Yuko Makita, Fetrina Oktavia, Tomoko Kuriyama, Yukio Kurihara, Hidefumi Hamasaki, Yuki Nakamura, Mitsutaka Kadota, Osamu Nishimura and 3 more

Abstract read
In one paragraph

Article in GigaScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nyok-Sean LauRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0000-0002-0708-5970
Emiko Okubo-KuriharaRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0000-0002-7171-7346
Yuko MakitaRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0000-0001-5745-6007
Fetrina OktaviaIndonesian Rubber Research Institute, Sembawa, Banyuasin 30953, Indonesia.ORCID 0000-0002-0271-6200
Tomoko KuriyamaRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.
Yukio KuriharaRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0000-0002-3149-8097
Hidefumi HamasakiRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0009-0001-8888-7448
Yuki NakamuraPlant Lipid Research Team, RIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0000-0003-2897-4301
Mitsutaka KadotaLaboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe 650-0047, Japan.ORCID 0000-0002-1674-6697
Osamu NishimuraLaboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe 650-0047, Japan.ORCID 0000-0003-1969-2580
Shigehiro KurakuLaboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe 650-0047, Japan.ORCID 0000-0003-1464-8388
Ahmad Sofiman OthmanCentre for Chemical Biology, Universiti Sains Malaysia, Bayan Lepas 11900 Penang, Malaysia.ORCID 0000-0002-4944-4177
Minami MatsuiRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0000-0001-5162-2668

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are multiple species within the Hevea genus, each exhibiting distinct characteristics, but many remain underexplored due to their lower latex productivity. While Hevea brasiliensis is the primary source of natural rubber, other Hevea species represent valuable gene pools that could be leveraged in breeding programs to enhance latex yield, biosynthesis efficiency, and the physicochemical properties of latex. With increasing interest in enhancing natural rubber traits, these lesser-known species are being revisited for their underexplored genetic diversity.

resultsIn this study, we performed a pangene analysis of 6 Hevea species and varieties, integrating proteomic and lipidomic data to investigate genetic and metabolic variation related to rubber biosynthesis and latex composition. The pangene analysis revealed conserved and expanded ATP-related functions, underscoring ATP's role in latex production. The proteomic data identified key enzymes involved in rubber biosynthesis and differentially abundant proteins related to latex regeneration, suggesting that regeneration capacity may influence yield efficiency. Lipidomic profiling uncovered species-specific lipid compositions associated with membrane dynamics and rubber particle stability, which may contribute to latex properties.

conclusionsThese findings provide valuable insights into Hevea's genomic and metabolic diversity, supporting future breeding programs aimed at improving natural rubber production and its performance in various applications.

Indexed as

GenomicsHeveaRubberEvolution, MolecularLatexLipidomicsMultiomicsPhylogenyPlant ProteinsProteomicsLatexPlant ProteinsRubbercomparative genomicsHevea specieslatex metabolismlipidomicsproteomicsrubber biosynthesis

Identifiers

PMID41070844
PMCPMC12512020

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.